Molecular Epidemiology of Lymphoma Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00488553
Recruitment Status : Withdrawn (No participants recruited, study discontinued.)
First Posted : June 20, 2007
Last Update Posted : February 24, 2012
Information provided by (Responsible Party):
M.D. Anderson Cancer Center

Brief Summary:

Primary Objectives:

  1. To enroll and obtain, through questionnaires, risk factor information on all study participants to develop detailed demographic, epidemiologic and behavioral profiles.
  2. To assess the influence of relevant epidemiologic covariates such as age, gender, smoking and family history of cancer on the panel of susceptibility biomarkers.
  3. To evaluate the role of genomic instability in development of lymphomas.

Condition or disease Intervention/treatment
Lymphoma Behavioral: Questionnaire

Detailed Description:

This study will include individuals diagnosed with lymphoma and individuals with no history of cancer. Half of the participants in this study will have lymphoma, and half will have no history of cancer. Information from both groups will be compared to help researchers try to learn which factors may lead to the development of lymphoma.

If you agree to take part in this study, you will be asked to complete a questionnaire at M. D. Anderson. In this questionnaire, you will be asked about your demographics (such as your age, sex, etc.), certain environmental exposures (such as pollution), your medical history, family history, diet, and your past and present smoking and alcohol use habits. This questionnaire should take about 50 minutes to complete.

You will also have about 2 ½ tablespoons of blood drawn for special tests. These tests will look for any biologic factors (such as changes in your DNA) that may be linked to lymphoma. You will not be informed of the results of any of the testing done with your blood samples.

Your participation will be over in this study once your blood has been drawn.

This is an investigational study. Up to 800 participants will take part in this study. All will be enrolled at M. D. Anderson.

Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Molecular Epidemiology of Lymphoma Patients
Study Start Date : August 2006
Actual Primary Completion Date : April 2008
Actual Study Completion Date : April 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Lymphoma

Group/Cohort Intervention/treatment
Participants of study with newly diagnosed lymphoma.
Behavioral: Questionnaire
Questions about cancer risk factors, medical history, and family history of cancer.
Other Name: Survey

Participants of study from matched control group.
Behavioral: Questionnaire
Questions about cancer risk factors, medical history, and family history of cancer.
Other Name: Survey

Primary Outcome Measures :
  1. To identify biologic (such as genes) and lifestyle factors that may increase a person's risk of developing lymphoma. [ Time Frame: 4 Years ]

Biospecimen Retention:   Samples With DNA
Subjects will also provide 30 cc of blood. The blood will be genotyped, and the genotype and epidemiological data will be used to evaluate the role of genomic instability (baseline and induced) in the development of lymphomas.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Participants in this study will include 400 with newly diagnosed lymphoma and 400 matched controls.

Inclusion Criteria:

  1. Cases only: Newly diagnosed, previously untreated patients with lymphoma as the primary cancer.
  2. Age 18 years and older.
  3. Willing to donate 30ml of blood.
  4. Willing to complete a self-administered questionnaire.
  5. Controls only: No prior cancer.

Exclusion Criteria:

  1. Cases only: Prior history of cancer other than lymphoma.
  2. Unable to speak or read English

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00488553

Sponsors and Collaborators
M.D. Anderson Cancer Center
Principal Investigator: Randa El-Zein, MD, PhD M.D. Anderson Cancer Center

Additional Information:
Responsible Party: M.D. Anderson Cancer Center Identifier: NCT00488553     History of Changes
Other Study ID Numbers: 2006-0281
First Posted: June 20, 2007    Key Record Dates
Last Update Posted: February 24, 2012
Last Verified: February 2012

Keywords provided by M.D. Anderson Cancer Center:
Lifestyle Factors

Additional relevant MeSH terms:
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases