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Trial record 7 of 74 for:    "Andersen-Tawil syndrome" OR "Long QT Syndrome"

The Long QT Syndrome in Pregnancy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00488254
Recruitment Status : Completed
First Posted : June 20, 2007
Last Update Posted : April 14, 2011
Information provided by:
University of British Columbia

Brief Summary:

Long QT Syndrome (LQTS) is a disease of young adults and can affect women of child bearing age. Suffers of LQTS are at risk of ventricular dysrhythmias including torsades de pointes and ventricular fibrillation.

Pregnancy increases the chance that any mother may have an abnormal heart rhythm or arrhythmia. This chance is higher with the LQTS. There are only a few reported cases of women with the LQTS having a baby in the medical literature. This can make it difficult for the doctor caring for a pregnant woman with the long QT syndrome - especially should they need an anesthetic.

We would like to study as many women who have had a baby who have the long QT syndrome to give us a better idea of whether there are any arrhythmias occurring at the time of delivery.

Condition or disease
Long QT Syndrome

Detailed Description:
This will be a retrospective analysis of all LQTS women managed at St. Paul's or BC Women's who have been pregnant in the last 5 years. These two hospitals both have a provincial role in the care of pregnant women, BC Women's as the designated provincial tertiary maternity care referral centre, and St. Paul's through its provincial PATCH clinic. Using the data from these two centres should capture the majority of LQTS cases in parturients in the province. We will search for these women from the Department of Anesthesia BC Women's consult database, the St. Paul's Cardiac Obstetrical Care database, and BC Women's Health Records using International Classification of Diseases - 10 coding for long QT. Then, after obtaining patient consent, review the charts collecting data using the data entry form. The cases will then be compared and any conclusions into the different anesthetic managements made.

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Study Type : Observational
Estimated Enrollment : 12 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: The Long QT Syndrome in Pregnancy
Study Start Date : June 2007
Actual Study Completion Date : April 2008

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Women managed at St. Paul's or BC Women's, Vancouver, who have been pregnant in the last 5 years

Inclusion Criteria:

  • Pregnant women with diagnoses of Long QT Syndrome, Romano Ward and Jervell - Lange Nielson Syndrome who delivered at BC Women's Hospital or St Paul's Hospital.

Exclusion Criteria:

  • Non consent to participation in the study
  • Age less than 19
  • Non English speaker

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00488254

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Canada, British Columbia
BC Women's Hospital
Vancouver, British Columbia, Canada
Sponsors and Collaborators
University of British Columbia
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Principal Investigator: Roanne Preston, MD University of British Columbia
Study Director: Elizabeth Drake, MD University of British Columbia
Study Director: Joanne Douglas, MD University of British Columbia
Study Director: Marla Kiess, MD University of British Columbia
Study Director: Stanley Tung, MD University of British Columbia

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Responsible Party: Dr. Roanne Preston, University of British Columbia Identifier: NCT00488254     History of Changes
Other Study ID Numbers: H06-03385
First Posted: June 20, 2007    Key Record Dates
Last Update Posted: April 14, 2011
Last Verified: April 2011

Keywords provided by University of British Columbia:
Long QT Syndrome
Romano Ward
Jervell-Lange Nielson Syndrome

Additional relevant MeSH terms:
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Long QT Syndrome
Pathologic Processes
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Cardiac Conduction System Disease
Heart Defects, Congenital
Cardiovascular Abnormalities
Congenital Abnormalities