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Study of Mental Fatigue in Polio Survivors

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2007 by Uniformed Services University of the Health Sciences.
Recruitment status was:  Recruiting
Information provided by:
Uniformed Services University of the Health Sciences Identifier:
First received: June 14, 2007
Last updated: June 15, 2007
Last verified: March 2007
Post-Poliomyelitis Syndrome (PPS) is the term describing the new problems affecting polio survivors many years after recovery from paralytic polio. Among the symptoms, fatigue is one of the most frequent and debilitating. In addition to physical incapacitation, the fatigue of PPS also affects mental function. The term “brain fatigue” is usually used by patients to express problems on the areas of attention, concentration, memory and clear thinking. Unfortunately, little is known about cognitive fatigue of PPS patients. This study is meant to examine if mental impairment is present in PPS patients and, if so, how it interferes on the self-function of patients. Patients will undergo an interview, clinical and neurological evaluation, and a battery of screening laboratory tests to make sure they are eligible for the study. Patients who qualify will undergo neuropsychometric tests in order to assay performance in the main areas of cognitive functioning. Through this organized approach we expect to be able to determine if mental fatigue is a significant problem affecting polio survivors, what areas are most affected, and how it may interfere with daily living.

Post-Poliomyelitis Syndrome

Study Type: Observational
Study Design: Allocation: Random Sample
Time Perspective: Cross-Sectional
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Uniformed Services University of the Health Sciences:


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • 18 years of age or older
  • Be a survivor of poliomyelitis
  • Willing to attend two clinic visits for completion of screening procedures and required tests

Exclusion Criteria:

  • Suffer from medical conditions that can interfere with cognitive function, including stroke, traumatic brain injury, dementia (progressive memory loss), severe depression, psychosis or other psychiatric disorders, etc.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00487487

Contact: Sandra Maxwell, RN 301-9840400

United States, Maryland
Postpolio Syndrome Outpatient Research Office Recruiting
Rockville, Maryland, United States, 20852
Contact: Sandra Maxwell, RN    301-984-0400   
Sub-Investigator: Olavo M Vasconcelos, MD         
Sponsors and Collaborators
Uniformed Services University of the Health Sciences
  More Information Identifier: NCT00487487     History of Changes
Other Study ID Numbers: USUHS-G192EI
Study First Received: June 14, 2007
Last Updated: June 15, 2007

Keywords provided by Uniformed Services University of the Health Sciences:
Candidates for this study are survivors of paralytic poliomyelitis

Additional relevant MeSH terms:
Postpoliomyelitis Syndrome
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Virus Diseases
Central Nervous System Infections
Central Nervous System Diseases
Nervous System Diseases
Spinal Cord Diseases
Neuromuscular Diseases
Muscular Disorders, Atrophic
Muscular Diseases
Musculoskeletal Diseases
Neurodegenerative Diseases processed this record on September 19, 2017