Insulin Resistance : Heart Failure

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00486967
Recruitment Status : Unknown
Verified June 2007 by University of Dundee.
Recruitment status was:  Recruiting
First Posted : June 15, 2007
Last Update Posted : June 15, 2007
Information provided by:
University of Dundee

Brief Summary:

Whether insulin resistance common among Chronic Heart Failure (CHF) patients in Tayside and identify factors associated with insulin resistance in CHF.

We also want to identify mechanism for the impaired exercise capacity and reduced peak VO2 in CHF

Condition or disease
Congestive Heart Failure Heart Failure

  Show Detailed Description

Study Type : Observational
Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Insulin Resistance: A New Target in Heart Failure
Study Start Date : August 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Failure

Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • One hundred patients with Left ventricular Ejection Friction (LVEF) <35% in NYHA class I II III or IV; aged 30-90, attending the CHF clinic will be studied
  • Diagnosis of CHF will be based on medical history of exertional dyspneoa, muscle fatigue and/or fluid retention and diminished LVEF (LVEF<35%)
  • The diagnosis of ischemic heart disease will be based on documentation of previous myocardial infarction, coronary artery bypass surgery or pathologic findings on coronary angiography. Idiopathic dilated cardiomyopathy will be diagnosed in the absence of a specific etiology for left ventricular dysfunction and on the basis of normal coronary arteries
  • All patients should be stable with their treatment and no change in their treatment regimen for > 6 weeks before the study
  • Patients with CHF due to coronary artery disease are more likely to have abnormalities in glucose metabolism than are patients with CHF due to idiopathic dilated cardiomyopathy. Therefore, we also plan to study a control group [n=50] of age and sex and BMI matched patients divided into 2 groups 25 with coronary artery disease without heart failure and 25 healthy control. These patients will be identified from the Cardiology Clinics

Exclusion Criteria:

  • Patients with decompensated CHF with signs of congestion
  • Since the objective of the study is to assess prevalence of insulin resistance in CHF and not CHF secondary to other diseases like diabetes mellitus (DM), patients suffering from DM will be excluded
  • Individual found during study cognitively impaired rendering them incapable to take part

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00486967

Contact: Matlooba A ALZadjali, BSc, MD, MPH 0044(0)1382 660111 ext 33176

United Kingdom
University of Dundee Recruiting
Dundee, United Kingdom, DD1 9SY
Contact: James Houston    0044(0)1382384664   
Sub-Investigator: MATLOOBA A ALZadjali, BSC,MD,MPH         
Sponsors and Collaborators
University of Dundee
Principal Investigator: Chim C Lang, MD, FRCP University of Dundee, Scotland, UK

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00486967     History of Changes
Other Study ID Numbers: MAT001
First Posted: June 15, 2007    Key Record Dates
Last Update Posted: June 15, 2007
Last Verified: June 2007

Keywords provided by University of Dundee:
Insulin resistance, heart failure, congestive heart failure,
Peak VO2, Endothelial Function, Leptin, TNF.

Additional relevant MeSH terms:
Heart Failure
Insulin Resistance
Heart Diseases
Cardiovascular Diseases
Glucose Metabolism Disorders
Metabolic Diseases
Hypoglycemic Agents
Physiological Effects of Drugs