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Anger Control Training for Youth With Tourette Syndrome

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00486551
First Posted: June 14, 2007
Last Update Posted: June 14, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
National Institute of Mental Health (NIMH)
Tourette Association of America
Information provided by:
Yale University
  Purpose
This is a clinical study of a cognitive-behavioral therapy known as anger control training in adolescents with Tourette Syndrome and explosive, disruptive behavior. ACT is compared to treatment as usual (TAU) in a randomized clinical trial.

Condition Intervention
Tourette Syndrome Chronic Tic Disorder Oppositional Defiant Disorder ADHD Behavioral: Anger control training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Treatment
Official Title: Anger Control Training for Youth With Tourette Syndrome

Resource links provided by NLM:


Further study details as provided by Yale University:

Primary Outcome Measures:
  • CGI-I assigned by clinician unaware of treatment assignment [ Time Frame: three months ]
  • Parent rated disruptive behavior [ Time Frame: three months ]

Enrollment: 26
Study Start Date: August 2001
Study Completion Date: January 2006
Detailed Description:
This is a randomized controlled study of a cognitive-behavioral, anger control training (ACT) in adolescents with Tourette Syndrome (TS) complicated by disruptive behavior. Disruptive behaviors in TS may take numerous forms including noncompliance, anger outbursts, and physical aggression. Anger outbursts in TS have been described as rage attacks or rage storms due to their high intensity and unpredictability in response to minimal provocation. Whether these behaviors are part of TS, related to comorbid conditions, or due to the burden of chronic illness is not clear. Nevertheless, these disruptive behaviors can result in significant functional impairment and often require clinical attention. The purpose of the ACT intervention is to improve the explosive and noncompliant behavior in adolescents with TS by enhancing affect regulation and social problem-solving skills. The treatment is based on anger control training which has been empirically supported for reducing aggressive behaviors and improving social functioning in aggressive youths. The primary outcome measures include the parent-rated Oppositional Defiant Scale and the Clinicians Global Improvement Score assessed by a clinician blind to treatment assignment.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   11 Years to 16 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Boys and girls, 11 to 16 years of age.
  2. Diagnosis of Tourette syndrome (TS) or chronic tic disorder (CTD).
  3. Significant level of disruptive behavior

Exclusion Criteria:

  1. Current diagnosis of Severe Major Depression, Bipolar Disorder, Pervasive Developmental Disorder, or Psychotic Disorder.
  2. Significant medical condition such as heart disease, hypertension, liver or renal failure, pulmonary disease, seizure disorder that may require more pressing treatment.
  3. Initiation or discontinuation of a psychotropic medication treatment within six weeks of enrollment in the study
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00486551


Locations
United States, Connecticut
Yale University School of Medicine, Child Study Center
New Haven, Connecticut, United States, 06520
Sponsors and Collaborators
Yale University
National Institute of Mental Health (NIMH)
Tourette Association of America
Investigators
Principal Investigator: Denis G Sukhodolsky, Ph.D. Yale University
Principal Investigator: Lawrence D Scahill, Ph.D. Yale University
  More Information

Additional Information:
Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00486551     History of Changes
Other Study ID Numbers: 1R03MH067845 ( U.S. NIH Grant/Contract )
First Submitted: June 12, 2007
First Posted: June 14, 2007
Last Update Posted: June 14, 2007
Last Verified: June 2007

Keywords provided by Yale University:
Anger control training
Cognitive behavioral therapy
Behavior therapy
Tourette Syndrome
Randomized trial
Anger
Aggression

Additional relevant MeSH terms:
Disease
Syndrome
Tourette Syndrome
Tic Disorders
Tics
Attention Deficit and Disruptive Behavior Disorders
Pathologic Processes
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Heredodegenerative Disorders, Nervous System
Neurodegenerative Diseases
Genetic Diseases, Inborn
Neurodevelopmental Disorders
Mental Disorders
Dyskinesias
Neurologic Manifestations
Signs and Symptoms