Angiotensin Converting Enzyme Inhibitors in Marfan Syndrome

This study has been completed.
Baker Heart Research Institute
The Alfred
Information provided by:
Bayside Health Identifier:
First received: June 11, 2007
Last updated: June 12, 2007
Last verified: June 2007
The purpose of this research is to assess the effects of a drug called perindopril on the aorta in people known to have Marfan Syndrome. The aorta is the major artery of the body that comes out of the heart and supplies blood to the body. We know that in people with Marfan Syndrome, the aorta is stiff and this stiffness results in its enlargement over many years. This enlargement of the aorta can be very serious. We know from treatment of other heart conditions that drugs of the same type as perindopril reduce stiffness of the arteries. This type of drug has never been tried in people with Marfan Syndrome.

Condition Intervention Phase
Marfan Syndrome
Drug: Coversyl (perindopril)
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Prevention
Official Title: The Effect of an Angiotensin Converting Enzyme Inhibitor on Aortic Wall Properties in Patients With Marfan Syndrome.

Resource links provided by NLM:

Further study details as provided by Bayside Health:

Primary Outcome Measures:
  • aortic root diameter [ Time Frame: 24 weeks ]

Secondary Outcome Measures:
  • arterial stiffness [ Time Frame: 24 weeks ]

Enrollment: 17
Study Start Date: January 2004
Study Completion Date: September 2006

Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age 18-40
  • Diagnosis of Marfan Syndrome, on the basis of the Ghent Criteria

Exclusion Criteria:

  • Age <18, >40
  • Women of child-bearing potential not on adequate contraception
  • Serum creatinine of >0.11
  • A history of intolerance to ACEI
  • Patients on angiotensin receptor blockers
  • Blood pressure >140/90mmHg
  • History of previous aortic surgery
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Please refer to this study by its identifier: NCT00485368

Sponsors and Collaborators
Bayside Health
Baker Heart Research Institute
The Alfred
Principal Investigator: Bronwyn A Kingwell, PhD Baker Heart Research Institute
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00485368     History of Changes
Other Study ID Numbers: 3/03 
Study First Received: June 11, 2007
Last Updated: June 12, 2007
Health Authority: Australia: Department of Health and Ageing Therapeutic Goods Administration

Keywords provided by Bayside Health:
marfan syndrome
aortic root diameter

Additional relevant MeSH terms:
Marfan Syndrome
Abnormalities, Multiple
Bone Diseases
Bone Diseases, Developmental
Cardiovascular Abnormalities
Cardiovascular Diseases
Congenital Abnormalities
Connective Tissue Diseases
Genetic Diseases, Inborn
Heart Defects, Congenital
Heart Diseases
Limb Deformities, Congenital
Musculoskeletal Abnormalities
Musculoskeletal Diseases
Pathologic Processes
Angiotensin-Converting Enzyme Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Protease Inhibitors processed this record on May 30, 2016