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Effect of Meal on Portal and Esophagus Variceal Pressure (VIPE)

This study has been terminated.
(No eligible patients were found, the study stopped without including any patients)
Information provided by:
Hvidovre University Hospital Identifier:
First received: June 11, 2007
Last updated: August 6, 2008
Last verified: November 2007
The reason why esophagus varices suddenly rupture and start to bleed is unclear. Food intake increase the hepatic blood flow and the portal pressure, but it is yet unknown if there is also an increase in variceal pressure. The aim of this study is to evaluate the efficacy of a meal on variceal pressure with a non invasive endoscopic measurement device, and compare it with portal pressure.

Condition Intervention
Cirrhosis Esophageal Varices Behavioral: meal (food intake)

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Effect of Meal on Portal and Esophagus Variceal Pressure

Resource links provided by NLM:

Further study details as provided by Hvidovre University Hospital:

Primary Outcome Measures:
  • effect of meal on variceal pressure [ Time Frame: 30 minutes after the meal ]

Enrollment: 0
Study Start Date: June 2007
Study Completion Date: April 2008
Primary Completion Date: April 2008 (Final data collection date for primary outcome measure)
Intervention Details:
    Behavioral: meal (food intake)
    600 kcal. (16% protein, 49%carbohydrate, 35% fatt)

Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Large Esophageal varices

Exclusion Criteria:

  • Treatment with beta-blocking agents
  • Respiratory diseases that contradict endoscopy
  • Gastric-retention
  • Former gastric resection
  • Resent sclerotherapy or former banding
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00485290

Hvidovre Hospital
Hvidovre, Denmark, 2650
Sponsors and Collaborators
Hvidovre University Hospital
Study Director: Flemming Bendtsen, MD, DMsc. Hvidovre University Hospital
  More Information

Responsible Party: Lise Hobolth, MD, Hvidovre Hospital Identifier: NCT00485290     History of Changes
Other Study ID Numbers: H-KF-2007-0050
Study First Received: June 11, 2007
Last Updated: August 6, 2008

Keywords provided by Hvidovre University Hospital:
cirrhosis, Portal Hypertension, Esophageal Varices, Meal

Additional relevant MeSH terms:
Esophageal and Gastric Varices
Pathologic Processes
Esophageal Diseases
Gastrointestinal Diseases
Digestive System Diseases
Hypertension, Portal
Liver Diseases processed this record on September 20, 2017