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Anti-inflammatory Therapy Following Selective Laser Trabeculoplasty

This study has been completed.
Glaucoma Research Society of Canada
Information provided by (Responsible Party):
Robert Campbell, Queen's University Identifier:
First received: June 9, 2007
Last updated: October 17, 2011
Last verified: October 2011

The type of anti-inflammatory medication used post selective laser trabeculoplasty (SLT) may have an impact on the intra-ocular pressure (IOP) lowering effect of SLT. This study will evaluate the IOP lowering effect of SLT following the topical administration of one of the following: prednisolone 1%, ketorolac 0.5% or artificial tears.

Condition Intervention
Primary Open Angle Glaucoma
Pseudo-exfoliative Glaucoma
Drug: prednisolone 1%
Drug: ketorolac 0.5%
Drug: methyl cellulose drops (artificial tears)

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Anti-inflammatory Therapy Following Selective Laser Trabeculoplasty (SLT): A Randomized, Masked, Placebo Controlled Study

Resource links provided by NLM:

Further study details as provided by Queen's University:

Primary Outcome Measures:
  • Intraocular pressure lowering effect [ Time Frame: 1 hour, 2 days, 1 month, 3 months, 6 months and 1 year ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • intraocular pressure elevation [ Time Frame: 1 hour, 2 days, 1 month ] [ Designated as safety issue: Yes ]

Enrollment: 120
Study Start Date: January 2007
Study Completion Date: June 2009
Primary Completion Date: June 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
Prednisolone 1% eye drop
Drug: prednisolone 1%
eye drop once in each eye treated, 4 times / day for 5 days post-laser
Active Comparator: 2
ketorolac 0.5% eye drop
Drug: ketorolac 0.5%
eye drop once in each eye treated, 4 times / day for 5 days post-laser
Other Name: Acular
Placebo Comparator: 3
methyl cellulose eye drop (artificial tears)
Drug: methyl cellulose drops (artificial tears)
eye drop once in each eye treated, 4 times / day for 5 days post-laser
Other Name: Refresh Tears

Detailed Description:

Patients who have been chosen to undergo SLT for glaucoma will be randomized to receive one of prednisolone 1%, ketorolac 0.5% or artificial tears four times a day for 5 days following administration of the laser treatment. The IOP will be measured at various time points following SLT: 1 hour, 2 days, 1 week, 1 month, 3 months, 6 months, and 1 year.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • primary open angle glaucoma, pseudo exfoliation glaucoma

Exclusion Criteria:

  • previous incisional glaucoma surgery
  Contacts and Locations
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Please refer to this study by its identifier: NCT00485108

Canada, Ontario
Queen's University
Kingston, Ontario, Canada
Sponsors and Collaborators
Queen's University
Glaucoma Research Society of Canada
Principal Investigator: Rob J Campbell, MD, MSc Queen's University
Study Director: Delan Jinapriya, MD Queen's University
  More Information

No publications provided

Responsible Party: Robert Campbell, Assistant Professor, Queen's University Identifier: NCT00485108     History of Changes
Other Study ID Numbers: DJ1
Study First Received: June 9, 2007
Last Updated: October 17, 2011
Health Authority: Canada: Ethics Review Committee

Keywords provided by Queen's University:
primary open angle glaucoma
pseudo-exfoliative glaucoma
selective laser trabeculoplasty
intra ocular pressure
anti-inflammatory therapy
prednisolone acetate 1%
ketorolac tromethamine 0.5%

Additional relevant MeSH terms:
Glaucoma, Open-Angle
Eye Diseases
Ocular Hypertension
Anti-Inflammatory Agents
Antineoplastic Agents
Antineoplastic Agents, Hormonal
Hormones, Hormone Substitutes, and Hormone Antagonists
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses processed this record on March 01, 2015