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Effects of Abdominal Hot Compresses on Indocyanine Green Elimination in Healthy Subjects

This study has been completed.
Information provided by:
University Hospital Freiburg Identifier:
First received: June 8, 2007
Last updated: NA
Last verified: June 2007
History: No changes posted
We investigated, whether abdominal hot compresses effect hepatic blood flow. Our hypothesis was, that the hot compresses might either by local vasomotor-reflex or by decreasing the tone of the sympathetic nerve system increase hepatic blood flow.

Condition Intervention Phase
Procedure: abdominal hot compress
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Supportive Care
Official Title: Effects of Abdominal Hot Compresses on Indocyanine Green Elimination – a Randomized Cross Over Study in Healthy Subjects

Further study details as provided by University Hospital Freiburg:

Primary Outcome Measures:
  • Indocyanine green half life [ Time Frame: 40 minutes ]

Secondary Outcome Measures:
  • heart rate, blood pressure [ Time Frame: 40 minutes ]

Enrollment: 14
Study Start Date: September 2003
Study Completion Date: December 2003
Detailed Description:

Abdominal hot compresses are traditionally used by patients with liver diseases as self help. This study investigated the effect of abdominal hot compresses on hepatic blood flow measured by elimination of indocyanine green (ICG), a non-toxic green dye. It was presumed, that abdominal hot compresses increase hepatic blood flow either by local vasomotor-reflex or by decreasing the tone of the sympathetic nerve system.

In healthy volunteers ICG elimination was measured with and without hot compress at two investigations in a weekly interval. At each investigation ICG was injected as bolus after a rest period of 10 minutes. After the injection blood was taken in regular intervals for analysis of ICG concentration over a period of 40 minutes and half life was calculated.

The time interval between the investigations was 8 days, the sequence was randomly assigned.


Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy volunteers

Exclusion Criteria:

  • iodine allergy
  • any acute or chronic disease [with exception of pollinosis because it is common]
  • elevated levels of alanine amino transferase [ALT], aspartate amino transferase [AST], gamma glutamyltransferase [GGT] or bilirubin
  • heat urticaria
  • pregnancy
  • alcohol intake >30 g/d
  • any medication except contraceptives
  • body mass index (BMI) >30 kg/m2
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Please refer to this study by its identifier: NCT00484913

Department of Internal Medicine II, Freiburg University Hospital
Freiburg, Baden Württemberg, Germany, 79106
Sponsors and Collaborators
University Hospital Freiburg
Principal Investigator: Roman Huber, Dr. Department of Internal Medicine II, Freiburg University Hospital, Germany
  More Information

Additional Information:
Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00484913     History of Changes
Other Study ID Numbers: LW05
Study First Received: June 8, 2007
Last Updated: June 8, 2007

Keywords provided by University Hospital Freiburg:
healthy subjects processed this record on May 25, 2017