Effects of Abdominal Hot Compresses on Indocyanine Green Elimination in Healthy Subjects
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|ClinicalTrials.gov Identifier: NCT00484913|
Recruitment Status : Completed
First Posted : June 12, 2007
Last Update Posted : June 12, 2007
|Condition or disease||Intervention/treatment||Phase|
|Healthy||Procedure: abdominal hot compress||Phase 1|
Abdominal hot compresses are traditionally used by patients with liver diseases as self help. This study investigated the effect of abdominal hot compresses on hepatic blood flow measured by elimination of indocyanine green (ICG), a non-toxic green dye. It was presumed, that abdominal hot compresses increase hepatic blood flow either by local vasomotor-reflex or by decreasing the tone of the sympathetic nerve system.
In healthy volunteers ICG elimination was measured with and without hot compress at two investigations in a weekly interval. At each investigation ICG was injected as bolus after a rest period of 10 minutes. After the injection blood was taken in regular intervals for analysis of ICG concentration over a period of 40 minutes and half life was calculated.
The time interval between the investigations was 8 days, the sequence was randomly assigned.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||14 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Supportive Care|
|Official Title:||Effects of Abdominal Hot Compresses on Indocyanine Green Elimination – a Randomized Cross Over Study in Healthy Subjects|
|Study Start Date :||September 2003|
|Actual Study Completion Date :||December 2003|
- Indocyanine green half life [ Time Frame: 40 minutes ]
- heart rate, blood pressure [ Time Frame: 40 minutes ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00484913
|Department of Internal Medicine II, Freiburg University Hospital|
|Freiburg, Baden Württemberg, Germany, 79106|
|Principal Investigator:||Roman Huber, Dr.||Department of Internal Medicine II, Freiburg University Hospital, Germany|