Effects of Abdominal Hot Compresses on Indocyanine Green Elimination in Healthy Subjects
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Supportive Care
|Official Title:||Effects of Abdominal Hot Compresses on Indocyanine Green Elimination – a Randomized Cross Over Study in Healthy Subjects|
- Indocyanine green half life [ Time Frame: 40 minutes ]
- heart rate, blood pressure [ Time Frame: 40 minutes ]
|Study Start Date:||September 2003|
|Study Completion Date:||December 2003|
Abdominal hot compresses are traditionally used by patients with liver diseases as self help. This study investigated the effect of abdominal hot compresses on hepatic blood flow measured by elimination of indocyanine green (ICG), a non-toxic green dye. It was presumed, that abdominal hot compresses increase hepatic blood flow either by local vasomotor-reflex or by decreasing the tone of the sympathetic nerve system.
In healthy volunteers ICG elimination was measured with and without hot compress at two investigations in a weekly interval. At each investigation ICG was injected as bolus after a rest period of 10 minutes. After the injection blood was taken in regular intervals for analysis of ICG concentration over a period of 40 minutes and half life was calculated.
The time interval between the investigations was 8 days, the sequence was randomly assigned.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00484913
|Department of Internal Medicine II, Freiburg University Hospital|
|Freiburg, Baden Württemberg, Germany, 79106|
|Principal Investigator:||Roman Huber, Dr.||Department of Internal Medicine II, Freiburg University Hospital, Germany|