Acetaminophen Versus Ibuprofen for the Control of Immediate and Delayed Pain Following Orthodontic Separator Placement
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The purpose of this research study is to compare pain control effectiveness of two medicines and a placebo (a dummy pill that does not contain any pain relieving medication) to see which one works better at preventing pain when taken both 1 hour before and 6 hours after orthodontic separators are placed. The research hypothesis is that there will be a significant difference in pain as measured by Visual Analogue Scales (VAS) over time and that this effect will differ for acetaminophen versus ibuprofen.
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Layout table for eligibility information
Ages Eligible for Study:
9 Years to 17 Years (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Orthodontic treatment requires banding of posterior teeth
Orthodontic treatment requires the placement of two or more separators
Able to swallow analgesic pills
Minimum weight requirement of 88 pounds
Orthodontic appliances are present in the mouth
Use of acetaminophen or ibuprofen is contraindicated (allergy, GI problems)
Antibiotics or analgesics are currently in use
History of systemic disease exists (arthritis, diabetes, cystic fibrosis)