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Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other

This study has been completed.
Information provided by:
Mashhad University of Medical Sciences Identifier:
First received: June 7, 2007
Last updated: June 8, 2007
Last verified: June 2007
Oral lichen planus (OLP) is a chronic inflammatory disorder which causes local irritation,discomfort and subsequent poor dentition and discomfort in eating . Various treatments have been suggested for OLP but their results are unsatisfactory .Despite the fact that steroids have been the main therapeutic choice for many years,some researches have been done regarding the efficacy of other medication such as metronidazole and doxycycline.The purpose of this study is to determine whether metronidazole and doxycycline are effective in the treatment of oral lichen planus and to compare their efficacy with each other.

Condition Intervention Phase
Oral Lichen Planus Drug: metronidazole,doxycycline Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Mashhad University of Medical Sciences:

Enrollment: 20
Study Start Date: September 2005
Study Completion Date: May 2006

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • a biopsy-proven untreated OLP of every type with no symptom.

Exclusion Criteria:

  • pregnancy, presence of dysplasia in lesions,unilateral lesion suspected lichenoid reaction,history of drinking alcohol in at least 1 month prior to the study, smoking, systemic disease, use of systemic medications and hypersensitivity to the metronidazole and doxycycline.
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Please refer to this study by its identifier: NCT00484250

Iran, Islamic Republic of
Mashhad University Of Medical Sciences(Dentistry School)
Mashhad, Khorasan, Iran, Islamic Republic of, 91375345
Sponsors and Collaborators
Mashhad University of Medical Sciences
Study Chair: Arash Mansourian, DDS,MS Tehran University of Medical Sciences
Study Director: Majid Sanatkhani, DDS,MS Mashhad University of Medical Sciences
Principal Investigator: Fatemeh Momen Heravi Tehran University of Medical Sciences
  More Information

Additional Information: Identifier: NCT00484250     History of Changes
Other Study ID Numbers: 240
Study First Received: June 7, 2007
Last Updated: June 8, 2007

Keywords provided by Mashhad University of Medical Sciences:
Oral Lichen Planus

Additional relevant MeSH terms:
Lichen Planus
Lichen Planus, Oral
Lichenoid Eruptions
Skin Diseases, Papulosquamous
Skin Diseases
Mouth Diseases
Stomatognathic Diseases
Anti-Infective Agents
Antiprotozoal Agents
Antiparasitic Agents
Anti-Bacterial Agents
Antimalarials processed this record on August 18, 2017