Genomic Search for Childhood Obesity Genes-A Pilot Study

The recruitment status of this study is unknown because the information has not been verified recently.

Verified May 2007 by Children's Mercy Hospital Kansas City.
Recruitment status was Not yet recruiting

Sponsor:

Information provided by:

Children's Mercy Hospital Kansas City

ClinicalTrials.gov Identifier:

NCT00484172

First received: June 7, 2007

Last updated: NA

Last verified: May 2007

History: No changes posted

Purpose

The purpose of this study is to screen a pediatric population (ages 2-8) for genes associated with childhood obesity.

Condition	Intervention
Obesity	Procedure: blood draws


Study Type:	Observational
Study Design:	Observational Model: Defined Population Primary Purpose: Screening Time Perspective: Longitudinal Time Perspective: Prospective
Official Title:	Genomic Search for Childhood Obesity Genes-A Pilot Study

Resource links provided by NLM:

MedlinePlus related topics: Genes and Gene Therapy

U.S. FDA Resources

Further study details as provided by Children's Mercy Hospital Kansas City:


Estimated Enrollment:	500
Study Start Date:	June 2007
Estimated Study Completion Date:	June 2008

Detailed Description:

The incidence of childhood obesity has been growing at an epidemic rate for the past several years, in part due to the lack of understanding of mechanisms at a molecular level. This study will screen a healthy general pediatric population age 2 to 8 for potential genes associated with childhood obesity using whole genomic gene arrays. Patients with BMI values equal to or greater than the 85th percentile will be compared to patients with a BMI below or equal to the 15th percentile. The INSIG2 gene will be specifically studied because of its identification in several populations of obese subjects. The differences in gene expression of the 2 groups will then be used to identify new genes for investigation in childhood obesity.

Eligibility


Ages Eligible for Study:	2 Years to 8 Years (Child)
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Ages 2-8, predominately Caucasian to minimize population stratification

Exclusion Criteria:

Chronic diseases (diabetes, cancer, etc) and known syndromes

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00484172

Contacts


Contact: Merlin G Butler, M.D., Ph.D.	816-234-3290	mgbutler@cmh.edu
Contact: Duane T Brandau, D.O., Ph.D.	816-460-1017	dtbrandau@cmh.edu

Locations


United States, Missouri
Children's Mercy Hospital	Not yet recruiting
Kansas City, Missouri, United States, 64108
Contact: Merlin G Butler, M.D., Ph.D. 816-234-3290 mgbutler@cmh.edu
Sub-Investigator: Uttam Garg, Ph.D.
Sub-Investigator: Hong-Wen Dong, Ph.D.

Sponsors and Collaborators

Children's Mercy Hospital Kansas City

Investigators


Principal Investigator:	Merlin G Butler, M.D., Ph.D.	Children's Mercy Hospital

More Information


ClinicalTrials.gov Identifier:	NCT00484172 History of Changes
Other Study ID Numbers:	07 03-045E
Study First Received:	June 7, 2007
Last Updated:	June 7, 2007
Health Authority:	United States: National Institutes of Health

Keywords provided by Children's Mercy Hospital Kansas City:


Obesity

Additional relevant MeSH terms:


Obesity Pediatric Obesity Overnutrition Nutrition Disorders	Overweight Body Weight Signs and Symptoms

ClinicalTrials.gov processed this record on September 28, 2016

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