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Genomic Search for Childhood Obesity Genes-A Pilot Study

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2007 by Children's Mercy Hospital Kansas City.
Recruitment status was:  Not yet recruiting
Information provided by:
Children's Mercy Hospital Kansas City Identifier:
First received: June 7, 2007
Last updated: NA
Last verified: May 2007
History: No changes posted
The purpose of this study is to screen a pediatric population (ages 2-8) for genes associated with childhood obesity.

Condition Intervention
Procedure: blood draws

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Genomic Search for Childhood Obesity Genes-A Pilot Study

Resource links provided by NLM:

Further study details as provided by Children's Mercy Hospital Kansas City:

Estimated Enrollment: 500
Study Start Date: June 2007
Estimated Study Completion Date: June 2008
Detailed Description:
The incidence of childhood obesity has been growing at an epidemic rate for the past several years, in part due to the lack of understanding of mechanisms at a molecular level. This study will screen a healthy general pediatric population age 2 to 8 for potential genes associated with childhood obesity using whole genomic gene arrays. Patients with BMI values equal to or greater than the 85th percentile will be compared to patients with a BMI below or equal to the 15th percentile. The INSIG2 gene will be specifically studied because of its identification in several populations of obese subjects. The differences in gene expression of the 2 groups will then be used to identify new genes for investigation in childhood obesity.

Ages Eligible for Study:   2 Years to 8 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Ages 2-8, predominately Caucasian to minimize population stratification

Exclusion Criteria:

  • Chronic diseases (diabetes, cancer, etc) and known syndromes
  Contacts and Locations
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Please refer to this study by its identifier: NCT00484172

Contact: Merlin G Butler, M.D., Ph.D. 816-234-3290
Contact: Duane T Brandau, D.O., Ph.D. 816-460-1017

United States, Missouri
Children's Mercy Hospital Not yet recruiting
Kansas City, Missouri, United States, 64108
Contact: Merlin G Butler, M.D., Ph.D.    816-234-3290   
Sub-Investigator: Uttam Garg, Ph.D.         
Sub-Investigator: Hong-Wen Dong, Ph.D.         
Sponsors and Collaborators
Children's Mercy Hospital Kansas City
Principal Investigator: Merlin G Butler, M.D., Ph.D. Children's Mercy Hospital
  More Information Identifier: NCT00484172     History of Changes
Other Study ID Numbers: 07 03-045E
Study First Received: June 7, 2007
Last Updated: June 7, 2007

Keywords provided by Children's Mercy Hospital Kansas City:

Additional relevant MeSH terms:
Pediatric Obesity
Nutrition Disorders
Body Weight
Signs and Symptoms processed this record on May 22, 2017