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Genomic Search for Childhood Obesity Genes-A Pilot Study
The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2007 by Children's Mercy Hospital Kansas City.
Recruitment status was: Not yet recruiting
Recruitment status was: Not yet recruiting
Sponsor:
Children's Mercy Hospital Kansas City
Information provided by:
Children's Mercy Hospital Kansas City
ClinicalTrials.gov Identifier:
NCT00484172
First received: June 7, 2007
Last updated: NA
Last verified: May 2007
History: No changes posted
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Purpose
The purpose of this study is to screen a pediatric population (ages 2-8) for genes associated with childhood obesity.
| Condition | Intervention |
|---|---|
| Obesity | Procedure: blood draws |
| Study Type: | Observational |
| Study Design: | Observational Model: Defined Population Primary Purpose: Screening Time Perspective: Longitudinal Time Perspective: Prospective |
| Official Title: | Genomic Search for Childhood Obesity Genes-A Pilot Study |
Resource links provided by NLM:
Further study details as provided by Children's Mercy Hospital Kansas City:
| Estimated Enrollment: | 500 |
| Study Start Date: | June 2007 |
| Estimated Study Completion Date: | June 2008 |
The incidence of childhood obesity has been growing at an epidemic rate for the past several years, in part due to the lack of understanding of mechanisms at a molecular level. This study will screen a healthy general pediatric population age 2 to 8 for potential genes associated with childhood obesity using whole genomic gene arrays. Patients with BMI values equal to or greater than the 85th percentile will be compared to patients with a BMI below or equal to the 15th percentile. The INSIG2 gene will be specifically studied because of its identification in several populations of obese subjects. The differences in gene expression of the 2 groups will then be used to identify new genes for investigation in childhood obesity.
Eligibility| Ages Eligible for Study: | 2 Years to 8 Years (Child) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- Ages 2-8, predominately Caucasian to minimize population stratification
Exclusion Criteria:
- Chronic diseases (diabetes, cancer, etc) and known syndromes
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00484172
Please refer to this study by its ClinicalTrials.gov identifier: NCT00484172
Contacts
| Contact: Merlin G Butler, M.D., Ph.D. | 816-234-3290 | mgbutler@cmh.edu | |
| Contact: Duane T Brandau, D.O., Ph.D. | 816-460-1017 | dtbrandau@cmh.edu |
Locations
| United States, Missouri | |
| Children's Mercy Hospital | Not yet recruiting |
| Kansas City, Missouri, United States, 64108 | |
| Contact: Merlin G Butler, M.D., Ph.D. 816-234-3290 mgbutler@cmh.edu | |
| Sub-Investigator: Uttam Garg, Ph.D. | |
| Sub-Investigator: Hong-Wen Dong, Ph.D. | |
Sponsors and Collaborators
Children's Mercy Hospital Kansas City
Investigators
| Principal Investigator: | Merlin G Butler, M.D., Ph.D. | Children's Mercy Hospital |
More Information
| ClinicalTrials.gov Identifier: | NCT00484172 History of Changes |
| Other Study ID Numbers: |
07 03-045E |
| Study First Received: | June 7, 2007 |
| Last Updated: | June 7, 2007 |
Keywords provided by Children's Mercy Hospital Kansas City:
|
Obesity |
Additional relevant MeSH terms:
|
Obesity Pediatric Obesity Overnutrition Nutrition Disorders |
Overweight Body Weight Signs and Symptoms |
ClinicalTrials.gov processed this record on June 26, 2017