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Genomic Search for Childhood Obesity Genes-A Pilot Study

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ClinicalTrials.gov Identifier: NCT00484172
Recruitment Status : Unknown
Verified May 2007 by Children's Mercy Hospital Kansas City.
Recruitment status was:  Not yet recruiting
First Posted : June 8, 2007
Last Update Posted : June 8, 2007
Sponsor:
Information provided by:
Children's Mercy Hospital Kansas City

Study Description
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Brief Summary:
The purpose of this study is to screen a pediatric population (ages 2-8) for genes associated with childhood obesity.

Condition or disease Intervention/treatment
Obesity Procedure: blood draws

Detailed Description:
The incidence of childhood obesity has been growing at an epidemic rate for the past several years, in part due to the lack of understanding of mechanisms at a molecular level. This study will screen a healthy general pediatric population age 2 to 8 for potential genes associated with childhood obesity using whole genomic gene arrays. Patients with BMI values equal to or greater than the 85th percentile will be compared to patients with a BMI below or equal to the 15th percentile. The INSIG2 gene will be specifically studied because of its identification in several populations of obese subjects. The differences in gene expression of the 2 groups will then be used to identify new genes for investigation in childhood obesity.

Study Design
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Study Type : Observational
Estimated Enrollment : 500 participants
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Genomic Search for Childhood Obesity Genes-A Pilot Study
Study Start Date : June 2007
Estimated Study Completion Date : June 2008

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U.S. FDA Resources

Groups and Cohorts
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Outcome Measures
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Eligibility Criteria
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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Ages Eligible for Study:   2 Years to 8 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Ages 2-8, predominately Caucasian to minimize population stratification

Exclusion Criteria:

  • Chronic diseases (diabetes, cancer, etc) and known syndromes
Contacts and Locations
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00484172


Contacts
Contact: Merlin G Butler, M.D., Ph.D. 816-234-3290 mgbutler@cmh.edu
Contact: Duane T Brandau, D.O., Ph.D. 816-460-1017 dtbrandau@cmh.edu

Locations
United States, Missouri
Children's Mercy Hospital Not yet recruiting
Kansas City, Missouri, United States, 64108
Contact: Merlin G Butler, M.D., Ph.D.    816-234-3290    mgbutler@cmh.edu   
Sub-Investigator: Uttam Garg, Ph.D.         
Sub-Investigator: Hong-Wen Dong, Ph.D.         
Sponsors and Collaborators
Children's Mercy Hospital Kansas City
Investigators
Principal Investigator: Merlin G Butler, M.D., Ph.D. Children's Mercy Hospital
More Information
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

ClinicalTrials.gov Identifier: NCT00484172     History of Changes
Other Study ID Numbers: 07 03-045E
First Posted: June 8, 2007    Key Record Dates
Last Update Posted: June 8, 2007
Last Verified: May 2007

Keywords provided by Children's Mercy Hospital Kansas City:
Obesity

Additional relevant MeSH terms:
Obesity
Pediatric Obesity
Overnutrition
Nutrition Disorders
 Overweight
Body Weight
Signs and Symptoms