Comment Period Extended to 3/23/2015 for Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials
Text Size

Genomic Search for Childhood Obesity Genes-A Pilot Study

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2007 by Children's Mercy Hospital Kansas City.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
Children's Mercy Hospital Kansas City
ClinicalTrials.gov Identifier:
NCT00484172
First received: June 7, 2007
Last updated: NA
Last verified: May 2007
History: No changes posted
  Purpose

The purpose of this study is to screen a pediatric population (ages 2-8) for genes associated with childhood obesity.


Condition Intervention
Obesity
 Procedure: blood draws

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Official Title: Genomic Search for Childhood Obesity Genes-A Pilot Study

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Children's Mercy Hospital Kansas City:
Estimated Enrollment: 500
Study Start Date: June 2007
Estimated Study Completion Date: June 2008
Detailed Description:

The incidence of childhood obesity has been growing at an epidemic rate for the past several years, in part due to the lack of understanding of mechanisms at a molecular level. This study will screen a healthy general pediatric population age 2 to 8 for potential genes associated with childhood obesity using whole genomic gene arrays. Patients with BMI values equal to or greater than the 85th percentile will be compared to patients with a BMI below or equal to the 15th percentile. The INSIG2 gene will be specifically studied because of its identification in several populations of obese subjects. The differences in gene expression of the 2 groups will then be used to identify new genes for investigation in childhood obesity.

  Eligibility
Ages Eligible for Study:   2 Years to 8 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Ages 2-8, predominately Caucasian to minimize population stratification

Exclusion Criteria:

  • Chronic diseases (diabetes, cancer, etc) and known syndromes
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00484172

Contacts
Contact: Merlin G Butler, M.D., Ph.D. 816-234-3290 mgbutler@cmh.edu
Contact: Duane T Brandau, D.O., Ph.D. 816-460-1017 dtbrandau@cmh.edu

Locations
United States, Missouri
Children's Mercy Hospital Not yet recruiting
Kansas City, Missouri, United States, 64108
Contact: Merlin G Butler, M.D., Ph.D.    816-234-3290    mgbutler@cmh.edu   
Sub-Investigator: Uttam Garg, Ph.D.         
Sub-Investigator: Hong-Wen Dong, Ph.D.         
Sponsors and Collaborators
Children's Mercy Hospital Kansas City
Investigators
Principal Investigator: Merlin G Butler, M.D., Ph.D. Children's Mercy Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00484172     History of Changes
Other Study ID Numbers: 07 03-045E
Study First Received: June 7, 2007
Last Updated: June 7, 2007
Health Authority: United States: National Institutes of Health

Keywords provided by Children's Mercy Hospital Kansas City:
Obesity

ClinicalTrials.gov processed this record on March 03, 2015