Genomic Search for Childhood Obesity Genes-A Pilot Study
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ClinicalTrials.gov Identifier: NCT00484172
Recruitment Status :
(Study Withdrawn due to Investigator leaving)
The purpose of this study is to screen a pediatric population (ages 2-8) for genes associated with childhood obesity.
Condition or disease
Procedure: blood draws
The incidence of childhood obesity has been growing at an epidemic rate for the past several years, in part due to the lack of understanding of mechanisms at a molecular level. This study will screen a healthy general pediatric population age 2 to 8 for potential genes associated with childhood obesity using whole genomic gene arrays. Patients with BMI values equal to or greater than the 85th percentile will be compared to patients with a BMI below or equal to the 15th percentile. The INSIG2 gene will be specifically studied because of its identification in several populations of obese subjects. The differences in gene expression of the 2 groups will then be used to identify new genes for investigation in childhood obesity.
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Layout table for eligibility information
Ages Eligible for Study:
2 Years to 8 Years (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Children aged 2-8 years old
Ages 2-8, predominately Caucasian to minimize population stratification
Chronic diseases (diabetes, cancer, etc) and known syndromes