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Genomic Search for Childhood Obesity Genes-A Pilot Study

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ClinicalTrials.gov Identifier: NCT00484172
Recruitment Status : Withdrawn (Study Withdrawn due to Investigator leaving)
First Posted : June 8, 2007
Last Update Posted : January 6, 2021
Sponsor:
Information provided by (Responsible Party):
Children's Mercy Hospital Kansas City

Brief Summary:
The purpose of this study is to screen a pediatric population (ages 2-8) for genes associated with childhood obesity.

Condition or disease Intervention/treatment
Obesity Procedure: blood draws

Detailed Description:
The incidence of childhood obesity has been growing at an epidemic rate for the past several years, in part due to the lack of understanding of mechanisms at a molecular level. This study will screen a healthy general pediatric population age 2 to 8 for potential genes associated with childhood obesity using whole genomic gene arrays. Patients with BMI values equal to or greater than the 85th percentile will be compared to patients with a BMI below or equal to the 15th percentile. The INSIG2 gene will be specifically studied because of its identification in several populations of obese subjects. The differences in gene expression of the 2 groups will then be used to identify new genes for investigation in childhood obesity.

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Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Other
Time Perspective: Prospective
Official Title: Genomic Search for Childhood Obesity Genes-A Pilot Study
Actual Study Start Date : June 2007
Actual Primary Completion Date : June 2008
Actual Study Completion Date : June 2008

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Ages Eligible for Study:   2 Years to 8 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Children aged 2-8 years old
Criteria

Inclusion Criteria:

  • Ages 2-8, predominately Caucasian to minimize population stratification

Exclusion Criteria:

  • Chronic diseases (diabetes, cancer, etc) and known syndromes

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00484172


Locations
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United States, Missouri
Children's Mercy Hospital
Kansas City, Missouri, United States, 64108
Sponsors and Collaborators
Children's Mercy Hospital Kansas City
Investigators
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Principal Investigator: Merlin G Butler, M.D., Ph.D. Children's Mercy Hospital Kansas City
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Responsible Party: Children's Mercy Hospital Kansas City
ClinicalTrials.gov Identifier: NCT00484172    
Other Study ID Numbers: 07 03-045E
First Posted: June 8, 2007    Key Record Dates
Last Update Posted: January 6, 2021
Last Verified: January 2021
Keywords provided by Children's Mercy Hospital Kansas City:
Obesity
Additional relevant MeSH terms:
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Obesity
Pediatric Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight