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Activation of Polyamine Catabolism in Patients With Acute Pancreatitis

This study has been completed.
Information provided by:
University of Tampere Identifier:
First received: June 7, 2007
Last updated: NA
Last verified: June 2007
History: No changes posted

Background: Polyamines are essential compounds in all mammalian tissues. If tissue spermidine/spermine levels, however, dramatically decrease, the cellular survival is severely endangered. Transgenic animals, where the homeostasis of cellular polyamines can be disturbed and tissue spermidine/spermine levels are decreased, acute pancreatitis evolves, indicating pancreas to be one of the most vulnerable organs for tissue polyamine catabolism. On the other hand, our own data suggests that also in other models of acute experimental pancreatitis pancreatic polyamines are changed depending on the severity of pancreatitis in such a way that the more severe pancreatitis the lower are the pancreatic polyamine levels. Minor changes were observed also in rats undergoing sham operation only. In addition of pancreatic enzymes, inflammatory mediators are also involved in the pathophysiology of the disease. CRP, IL-6, IL-8, IL-10 and Procalcitonin are useful in predicting the severity of the disease, combination of IL-6 and IL-10 at admission can predict organ failure with sensitivity of 95 %, specificity of 88 %.

Hypothesis: Similar to experimental pancreatitis, blood polyamine changes are associated with acute pancreatitis also in the man. These changes are dependent on the severity of pancreatitis, but not on the etiology of pancreatitis. The changes are specific to acute pancreatitis compared with other intra-abdominal emergencies. The changes observed return to baseline during recovery. Furthermore, we assume that blood polyamine negatively correlates with IL-6, IL-8, and procalcitonin, and positively with IL-10.


Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by University of Tampere:

Study Start Date: January 2006
Study Completion Date: June 2007

Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Patients who are diagnosed as acute pancreatitis.
  • Patients who are diagnosed as either of gallstone, duodenal ulcer or bleeding, gastric ulcer or bleeding, irritable bowel syndrome, hernia, diverticulitis, retrocecal appendicitis with non-pancreatic acute abdominal pain.

Exclusion Criteria:

  • Patients who underwent operation
  • Patients who underwent recurrent acute pancreatitis
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Please refer to this study by its identifier: NCT00484042

Sponsors and Collaborators
University of Tampere
Principal Investigator: Isto H Nordback, M.D. Tampere University Hospital
  More Information Identifier: NCT00484042     History of Changes
Other Study ID Numbers: R06025
Study First Received: June 7, 2007
Last Updated: June 7, 2007

Keywords provided by University of Tampere:

Additional relevant MeSH terms:
Pancreatic Diseases
Digestive System Diseases processed this record on March 28, 2017