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Albumindialysis in Acute Pancreatitis (pancreatitis)

This study has suspended participant recruitment.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00483912
First Posted: June 8, 2007
Last Update Posted: June 8, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Tampere
  Purpose
The incidence of acute pancreatitis has been doubled during last three decades in Finland. Alcohol is the main cause of acute pancreatitis in Finland accounting for 70 % of cases. Although the mortality of acute pancreatitis has been decreased it still appears and especially early multiple organ failure is the main cause of all deaths. Multiple organ failure in the early course of the disease is thought to be caused by the release of cytokines. Molecular adsorbent recirculating system (MARS) has shown to decrease mortality in acute alcohol hepatitis and paracetamol intoxication. Also it has been shown to improve kidney function due to hypoperfusion and tubulus necrosis and overrule decrease mortality in patients with multiple organ failure due to different reasons. A part of patients with acute alcoholic pancreatitis may have so-called fat liver already on admission. It has been shown that the highest mortality is especially associated those with early liver and kidney failure. MARS treatment has never earlier been used in the patients with acute alcoholic pancreatitis and early organ failure. In this study we randomize patients with acute alcoholic pancreatitis and early multiple organ failure (Sofa score>2) to two groups: 1) Standard pancreatitis treatment in intensive care unit and 2) Standard pancreatitis treatment in intensive care unit with 5 MARS sessions.

Condition Intervention
Pancreatitis Multiple Organ Failure Device: Molecular adsorbent recirculating system

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Official Title: Molecular Adsorbent Recirculating System (MARS) in Severe Acute Pancreatitis

Resource links provided by NLM:


Further study details as provided by University of Tampere:

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Criteria

Inclusion Criteria:

  • Severe acute alcoholic pancreatitis with early multiple organ failure (Sofa score >2)

Exclusion Criteria:

  • If patient or his/her family member refuses, pregnancy.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00483912


Locations
Finland
Tampere University Hospital
Tampere, Finland, 33521
Sponsors and Collaborators
University of Tampere
Investigators
Study Chair: Sari Räty Dept. of Gastroenterology and Alimentary Tract Surgery
  More Information

ClinicalTrials.gov Identifier: NCT00483912     History of Changes
Other Study ID Numbers: R04005
First Submitted: June 7, 2007
First Posted: June 8, 2007
Last Update Posted: June 8, 2007
Last Verified: June 2007

Keywords provided by University of Tampere:
pancreatitis, MARS
severe acute pancreatitis with early multiple organ failure

Additional relevant MeSH terms:
Pancreatitis
Multiple Organ Failure
Pancreatic Diseases
Digestive System Diseases
Shock
Pathologic Processes