Coordination Versus Pressure in Oesophageal Peristalsis
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00482885|
Recruitment Status : Completed
First Posted : June 5, 2007
Last Update Posted : June 27, 2011
High Resolution Manometry (HRM) is a new advance in oesophageal measurement that permits the acquisition of pressure data through the entire length of the oesophagus over time via closely spaced sensors that continuously record the motor activity of the oesophagus. This allows not only contractile pressure to be measured, but also the coordination (proximal-distal) of contractions and the development of effective intra-bolus pressure (the force that drives bolus movement).
The study hypothesis is that (1) there will be a progressive increase in peristaltic pressure and decrease in velocity as the subjects move from the upright, through the supine to the upside down position and (2) the increase in pressure will be most evident in the mid-oesophagus at the transition zone between the striated and the smooth muscle contractions.
|Condition or disease|
Show Detailed Description
|Study Type :||Observational|
|Actual Enrollment :||25 participants|
|Official Title:||The Effect of Position on Oesophageal Peristalsis and LOS Pressures: a High Resolution Manometry Study|
|Study Start Date :||October 2007|
|Actual Primary Completion Date :||August 2010|
|Actual Study Completion Date :||August 2010|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00482885
|Oesophageal Laboratory, GSTT|
|London, United Kingdom, SE1 7EH|
|Principal Investigator:||Mark Fox, MD||Honorary Consultant and Senior Lecturer|