PCR-Based Detection of Bacterial Agents in Platelet Concentrates and Whole Blood
Recruitment status was Not yet recruiting
Using methods of molecular biology bacteria can be detected in blood. In comparison to conventional blood cultures "bacterial DNA" is isolated using a new sample preparation system in platelet apheresis concentrates and in the predonation whole blood of donors.
|Study Design:||Allocation: Random Sample
Primary Purpose: Screening
Time Perspective: Cross-Sectional
|Official Title:||PCR-Based Detection of Bacterial Agents in Platelet Concentrates and Whole Blood (First Study)|
|Study Start Date:||June 2007|
|Estimated Study Completion Date:||July 2009|
Bacterial contamination of platelet concentrates is discussed worldwide and according to literature occuring in 1:1000 to 1:5000 concentrates. Bacterial contaminated concentrates can in fact cause severe infections in patients. therefore this study initially intends to detect contamination with "bacterial DNA" in platelet aphereses concentrates. All sample donations are also examined by blood culture for contamination. To exclude already existing "infection" of the donor one tube of whole blood is taken in addition to the other legally required samples for the production of pharmaceutical medicine. All samples are anonymised before passed on for analysing.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00482339
|Institute for Transfusion Medicine, University Hospital Jena||Not yet recruiting|
|Jena, Thuringia, Germany, D-07743|
|Contact: Thomas Lorenzen, Dr. med. +49 3641 935475 firstname.lastname@example.org|
|Contact: Silke Rummler, Dr. med. +49 3641 9325593 email@example.com|
|Study Director:||Dagmar Barz, Prof Dr med.||University Hospital Jena, Germany|