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The Biology of Claudin 3 in Primary Human Mammary Epithelial Cell Culture

This study has been terminated.
(study team failed to complete timely reviews, study suspended)
Sponsor:
ClinicalTrials.gov Identifier:
NCT00481585
First Posted: June 1, 2007
Last Update Posted: February 4, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Hackensack University Medical Center
  Purpose

The objective of the present study is to determine whether or not primary human mammary epithelial cells are competent for use in molecular studies of transepithelial electrophysiology focusing on the function of the tight junction protein claudin 3.

Human breast Tissue will be removed from mastectomy specimens and used as a source to generate epithelial cells for study.


Condition
Breast Cancer

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Biology of Claudin 3 in Primary Human Mammary Epithelial Cell Culture

Resource links provided by NLM:


Further study details as provided by Hackensack University Medical Center:

Primary Outcome Measures:
  • Cell line data study [ Time Frame: one year ]

Enrollment: 13
Study Start Date: May 2007
Primary Completion Date: July 2009 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
13 subjects - Subjects of this pilot study are limited to those female patients who are undergoing therapeutic or prophylactic mastectomy procedures conducted by the department of Surgery at HUMC.
Criteria

Inclusion Criteria:

  • Subjects of this pilot study are limited to those female patients who are undergoing therapeutic or prophylactic mastectomy procedures conducted by the department of Surgery at HUMC.

Exclusion Criteria:

  • From within this population, no exclusion criteria shall be applied based on age, race, ethnicity, gender, HIV status, or menopause.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00481585


Locations
United States, New Jersey
Hackensack Univeristy Medical Center
Hackensack, New Jersey, United States, 07601
Sponsors and Collaborators
Hackensack University Medical Center
Investigators
Principal Investigator: Erik F Young, Ph.D. Hackensack University Medical Center
  More Information

Responsible Party: Hackensack University Medical Center
ClinicalTrials.gov Identifier: NCT00481585     History of Changes
Other Study ID Numbers: 07.01.041
First Submitted: May 30, 2007
First Posted: June 1, 2007
Last Update Posted: February 4, 2014
Last Verified: February 2014

Keywords provided by Hackensack University Medical Center:
claudin
electrophysiology
breast
screening