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Characteristics of Hgb C Carriers in Northern Israel and Clinical Features Among Hgb Homozygous

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ClinicalTrials.gov Identifier: NCT00481260
Recruitment Status : Completed
First Posted : June 1, 2007
Last Update Posted : September 4, 2009
Sponsor:
Information provided by:
HaEmek Medical Center, Israel

Brief Summary:

Hgb C is an hemoglobinopathy quite rare in Israel. The clinical status of patients that are diagnosed as homozygous to this disease is quite benign but not study in large groups.

Also the characteristics of carriers and the incidence in northern Israel were a large arab population lives, was not study. The results of this study can be useful for screening purpose in a area were another hemoglobinopathies are frequent.


Condition or disease Intervention/treatment
Hgb C Hemoglobinopathy Procedure: Medical history and basic laboratory analysis

Detailed Description:

Hgb C is an hemoglobinopathy quite rare in Israel. The clinical status of patients that are diagnosed as homozygous to this disease is quite benign but not study in large groups.

Also the characteristics of carriers and the incidence in northern Israel were a large arab population lives, was not study. The results of this study can be useful for screening purpose in a area were another hemoglobinopathies are frequent.

The study will record the clinical characteristics of the homozygous Hgb C patients and the hematology characteristics of all the heterozygous carriers detected in northern Israel


Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Characteristics of Hgb C Carriers in Northern Israel and Clinical Features Among Hgb Homozygous
Study Start Date : May 2007
Actual Primary Completion Date : December 2008
Actual Study Completion Date : December 2008

Intervention Details:
  • Procedure: Medical history and basic laboratory analysis
    Medical history and basic laboratory analysis



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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients diagnosed at the pediatric Hematology Unit of laboratory data from the thalassemia screening in northern Israel
Criteria

Inclusion Criteria:

  • All patients diagnosed as homozygous for Hgb C disease or double heterozygous in combination to other abnormal hemoglobin, and all the carriers detected in the hematology laboratory during the screening for abnormal hemoglobins in northern Israel

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00481260


Locations
Israel
Pediatric Hematology Unit - HaEmek Medical Center
Afula, Israel, 18101
Sponsors and Collaborators
HaEmek Medical Center, Israel
Investigators
Study Director: Ariel Koren, MD Pediatric Hematology Unit, Ha'Emek Medical Center
Study Chair: luci Zalman, Phd Hematology Laboratory - HaeEmek Medical Center

Responsible Party: Dr Koren Ariel, Pediatric Hematology Unit - HaEmek Medical Center - Afula - Israel
ClinicalTrials.gov Identifier: NCT00481260     History of Changes
Other Study ID Numbers: 5100706.EMC
First Posted: June 1, 2007    Key Record Dates
Last Update Posted: September 4, 2009
Last Verified: September 2009

Keywords provided by HaEmek Medical Center, Israel:
Hgb C
Screening

Additional relevant MeSH terms:
Hemoglobinopathies
Hematologic Diseases
Genetic Diseases, Inborn