In Vitro Maturation of Immature Oocytes

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00480337
Recruitment Status : Completed
First Posted : May 30, 2007
Last Update Posted : December 17, 2008
Information provided by:
Sheba Medical Center

Brief Summary:
The aim of this study is to aspirate immature oocytes from antral follicles and mature the oocytes in vitro. These mature oocytes will serve for fertilization and the creation of embryos which will be replace in the uterus as performed during normal IVF.We will record the efficacy and safety of this procedure.

Condition or disease Intervention/treatment Phase
Polycystic Ovary Syndrome Ovarian Hyperstimulation Syndrome Procedure: In Vitro Maturation of immature oocytes Not Applicable

Study Type : Interventional  (Clinical Trial)
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment

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U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Women with PCOS
  • Women with previous Hyperstimulation or with risk of developing hyperstimulation during IVF Treatment
  • Women diagnosed with cancer who are interested in fertility preservation
  • Women with repeated IVF failure

Exclusion Criteria:

  • Severe cases of endometriosis
  • Large myomas
  • Hydrosalpinxs Technical problem with previous oocytes pick-up

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00480337

IVF Unit, Shea Medical Center, Tel-Hashomer
Ramat-Gan, Israel, 52621
Sponsors and Collaborators
Sheba Medical Center
Principal Investigator: Ariel Hourvitz IVF Unit, Sheba Medical Center Identifier: NCT00480337     History of Changes
Other Study ID Numbers: SHEBA-06-4317-AH-CTIL
First Posted: May 30, 2007    Key Record Dates
Last Update Posted: December 17, 2008
Last Verified: December 2008

Keywords provided by Sheba Medical Center:
Fertility Preservation
Repeated IVF Failure
S/P Hyperstimulation

Additional relevant MeSH terms:
Polycystic Ovary Syndrome
Ovarian Hyperstimulation Syndrome
Pathologic Processes
Ovarian Cysts
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Gonadal Disorders
Endocrine System Diseases