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ClinicalTrials.gov Identifier: NCT00480129
Recruitment Status :
First Posted : May 30, 2007
Last Update Posted : August 11, 2015
Lawson Health Research Institute
Ontario Ministry of Agriculture, Food and Rural Affairs
We hypothesize that specifically selected probiotics can alleviate symptoms of allergy in lactose tolerant individuals. Two strains of probiotics, Lactobacillus rhamnosus GR-1, and Bifidobacterium adolescentis 7007-05 will be used to create a yogurt product. Additionally a non-probiotic yogurt product will also be made as a placebo. Allergy sufferers will be asked to consume one of the two types of yogurts (blinded) for two months. During the two months there will be 3 sampling days, for blood samples and nasal lavage samples. Additionally Mini Rhinoconjunctivitis Quality of Life Questionnaires will be filled out weekly over the two months. After the two months of perceived responses as well sample analysis we should have a better idea of how these specific probiotic effect the immune system and allergies.
Condition or disease
Behavioral: Probiotic or placebo yogurt consumed dailyDevice: Mini Rhinoconjunctivitis Quality of Life QuestionnaireProcedure: Blood sampleProcedure: Nasal lavage
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Ages Eligible for Study:
18 Years to 66 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Clinical diagnosis of allergic rhinitis based on sneeze attacks, runny/blocked/itchy nose in the absence of a common cold during the previous 12 months.
History of positive skin prick test or blood radio-allergosorbent test (RAST) to grass and/or ragweed pollen
Ongoing allergen immunotherapy
upper respiratory tract infection
Clinical history of lactose-intolerance or allergies to cow-milk