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A Preliminary Study on Effect of Omega-3 on Human Sperm

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2006 by Hadassah Medical Organization.
Recruitment status was:  Not yet recruiting
Shaare Zedek Medical Center
Information provided by:
Hadassah Medical Organization Identifier:
First received: May 28, 2007
Last updated: May 29, 2007
Last verified: November 2006

The phospholipids of mammalian spermatozoa possess a distinctive fatty acid composition with high proportion of long chain polyunsaturated fatty acids. The lipid composition is a major determinant of the membrane flexibility and sperm motility required for proper fertilization. It also influences the sperm plasma membrane's fluidity, chilling sensitivity and thermotropic lipid phase transition (LPT) and these parameters determine our ability to cryopreserve these cells. Our hypotheses is that by providing dietary supplementation of omega-3 polyunsaturated fatty acids an improvement of sperm parameters (number, motility, viability) can be achieved. We also expect alteration spermatozoal plasma membrane fatty acid composition, making it more chilling resistant.

Experimental methodology: 1) Characterize fatty acid composition of the spermatozoa of normal and abnormal spermatozoa by gas chromatography. 2) Characterize sperm plasma membrane LPT by FTIR spectrometer. 3) Run a randomized double-blind, placebo controlled, crossed-over dietary fatty acid supplementation pilot trial in human sub-fertile patients. Large scale trial will follow, if justified. In both trials sperm characterization of each participant will be conducted before, during and following the trial.

Subfertile males will benefit greatly if their sperm parameters can be improved and cryopreserved while ensuring enhanced post-thawing survival. We believe that changing the fatty acid composition of sperm plasma membrane by simple dietary means will open the way to improve the fertility of those that needs it the most.

Condition Intervention Phase
Oligospermia Behavioral: commercially available omega-3 fatty acids supplementation Early Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Effect of Dietary Supplementation With Omega-3 Fatty Acids on Human Sperm Characteristics, a Preliminary Study

Resource links provided by NLM:

Further study details as provided by Hadassah Medical Organization:

Primary Outcome Measures:
  • sperm count [ Time Frame: 10 weeks ]

Secondary Outcome Measures:
  • sperm Lipid phase transition determination [ Time Frame: 10 weeks ]

Estimated Enrollment: 20
Study Start Date: June 2007
Estimated Study Completion Date: June 2007
  Show Detailed Description


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Patients with asthenozoospermia (low progressive motility), teratozoopermia (abnormal morphology) and/or oligozoospermia (low sperm count)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00479960

Contact: Abraham Benchetrit, MD 97250-8962566
Contact: Ariel Revel, MD 97226776424

Shaare Zedek Medical Center Not yet recruiting
Jerusalem, Israel
Principal Investigator: Avraham Benchetrit, MD         
Sponsors and Collaborators
Hadassah Medical Organization
Shaare Zedek Medical Center
Principal Investigator: Ariel Revel, MD Hadassah university hospital
  More Information Identifier: NCT00479960     History of Changes
Other Study ID Numbers: 022006
Study First Received: May 28, 2007
Last Updated: May 29, 2007

Keywords provided by Hadassah Medical Organization:
Fatty Acids

Additional relevant MeSH terms:
Infertility, Male
Genital Diseases, Male processed this record on September 21, 2017