A Preliminary Study on Effect of Omega-3 on Human Sperm
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00479960|
Recruitment Status : Unknown
Verified November 2006 by Hadassah Medical Organization.
Recruitment status was: Not yet recruiting
First Posted : May 30, 2007
Last Update Posted : May 30, 2007
The phospholipids of mammalian spermatozoa possess a distinctive fatty acid composition with high proportion of long chain polyunsaturated fatty acids. The lipid composition is a major determinant of the membrane flexibility and sperm motility required for proper fertilization. It also influences the sperm plasma membrane's fluidity, chilling sensitivity and thermotropic lipid phase transition (LPT) and these parameters determine our ability to cryopreserve these cells. Our hypotheses is that by providing dietary supplementation of omega-3 polyunsaturated fatty acids an improvement of sperm parameters (number, motility, viability) can be achieved. We also expect alteration spermatozoal plasma membrane fatty acid composition, making it more chilling resistant.
Experimental methodology: 1) Characterize fatty acid composition of the spermatozoa of normal and abnormal spermatozoa by gas chromatography. 2) Characterize sperm plasma membrane LPT by FTIR spectrometer. 3) Run a randomized double-blind, placebo controlled, crossed-over dietary fatty acid supplementation pilot trial in human sub-fertile patients. Large scale trial will follow, if justified. In both trials sperm characterization of each participant will be conducted before, during and following the trial.
Subfertile males will benefit greatly if their sperm parameters can be improved and cryopreserved while ensuring enhanced post-thawing survival. We believe that changing the fatty acid composition of sperm plasma membrane by simple dietary means will open the way to improve the fertility of those that needs it the most.
|Condition or disease||Intervention/treatment||Phase|
|Oligospermia||Behavioral: commercially available omega-3 fatty acids supplementation||Early Phase 1|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||20 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||Effect of Dietary Supplementation With Omega-3 Fatty Acids on Human Sperm Characteristics, a Preliminary Study|
|Study Start Date :||June 2007|
|Estimated Study Completion Date :||June 2007|
- sperm count [ Time Frame: 10 weeks ]
- sperm Lipid phase transition determination [ Time Frame: 10 weeks ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00479960
|Contact: Abraham Benchetrit, MDfirstname.lastname@example.org|
|Contact: Ariel Revel, MDemail@example.com|
|Shaare Zedek Medical Center||Not yet recruiting|
|Principal Investigator: Avraham Benchetrit, MD|
|Principal Investigator:||Ariel Revel, MD||Hadassah university hospital|