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Non-Invasive Determination of Cardiac Output by Inertgas Rebreathing Method (NICO)

This study has been completed.
Information provided by:
Universitätsmedizin Mannheim Identifier:
First received: May 25, 2007
Last updated: June 4, 2008
Last verified: June 2008
The cardiac output (CO) is an important parameter in the diagnosis and therapy of cardiac diseases. The current standard methods for the determination of the CO, however, are either invasive (e.g. right heart catheterization) or technically expendable and expensive (magnetic resonance tomography, MRT). The traditional non-invasive methods of determining the CO by rebreathing of carbon dioxide are easily carried out but suffer from methodical inaccuracies. Therefore the aim of the study at hand was to evaluate a new method for determining the CO by means of the inert gas rebreathing method.

Condition Intervention
Cardiac Diseases Device: inertgas rebreathing Device: spirometry Device: cardiac magnetic resonance imaging (CMR)

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Non-Invasive Determination of Cardiac Output by the Inertgas Rebreathing Method Compared With Magnetic Resonance Tomography

Further study details as provided by Universitätsmedizin Mannheim:

Enrollment: 311
Study Start Date: August 2006
Study Completion Date: December 2007
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
Intervention Details:
    Device: inertgas rebreathing
    determination of cardiac output by inertgas rebreathing
    Device: spirometry
    spirometry for testing the ventilatory function
    Device: cardiac magnetic resonance imaging (CMR)
    CMR examination which delivers the hemodynamic reference parameters

Ages Eligible for Study:   14 Years to 90 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Study Population
Consecutive patients with indication for CMR

Inclusion Criteria:

  • Indication for CMR
  • Ability of following instructions for rebreathing test
  Contacts and Locations
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Please refer to this study by its identifier: NCT00479804

1st Department of Medicine, University Hospital Mannheim
Mannheim, Baden-Württemberg, Germany, 68167
Sponsors and Collaborators
Universitätsmedizin Mannheim
Study Director: Joachim Saur, Dr. 1st Department of Medicine
Study Chair: Jens Kaden, Dr. 1st Deparment of Medicine
  More Information

Responsible Party: Dr. Joachim Saur, University Hospital Mannheim Identifier: NCT00479804     History of Changes
Other Study ID Numbers: 2006-067M-MA
Study First Received: May 25, 2007
Last Updated: June 4, 2008

Keywords provided by Universitätsmedizin Mannheim:
indication for CMR

Additional relevant MeSH terms:
Heart Diseases
Cardiovascular Diseases processed this record on July 24, 2017