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Lipid, Glycemic, and Insulin Responses to Meals Rich in Different Fatty Acids

This study has been completed.
Information provided by:
University of Texas Southwestern Medical Center Identifier:
First received: May 24, 2007
Last updated: May 25, 2007
Last verified: May 2007
A meal rich in very-long chain omega-3 fatty acids or oleic acid may lower postprandial insulin levels in comparison to a meal rich in linoleic acid or palmitic acid. A meal rich in very long-chain omega-3 fatty acids may lower postprandial triglyceride levels compared to other fatty acids.

Condition Intervention
Type 2 Diabetes Mellitus
Behavioral: Test meals rich in different fatty acids

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Lipid, Glycemic, and Insulin Responses to Meals Rich in Saturated, Cis-Monounsaturated, and Polyunsaturated Fatty (n-3 and n-6)Acids in Subjects With Type 2 Diabetes Mellitus

Resource links provided by NLM:

Further study details as provided by University of Texas Southwestern Medical Center:

Primary Outcome Measures:
  • Insulin, and glucose [ Time Frame: 15 days ]

Secondary Outcome Measures:
  • Triglycerides [ Time Frame: 15 days ]

Enrollment: 11
Study Start Date: April 1997
Study Completion Date: June 1999
Detailed Description:
Research Design and Methods: Test meals rich in palmitic acid, linoleic acid, oleic acid, and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and containing 1,000 kcal each were administered in a randomized cross-over design every 3 to 4 days to 11 patients with T2DM. Serum insulin, glucose, and triglycerides concentrations were measured for 360 minutes. All subjects received an isoenergic diet of constant composition throughout the study.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Type 2 diabetes mellitus not on insulin therapy

Exclusion Criteria:

  • Thyroid, renal, or hepatic disease, uncontrolled hypertension, anemia, history of ketosis
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Please refer to this study by its identifier: NCT00479791

United States, Texas
UT Southwestern Medical Center at Dallas
Dallas, Texas, United States, 75235-9052
Sponsors and Collaborators
University of Texas Southwestern Medical Center
Study Chair: Abhimanyu Garg, MD UT Southwestern Medical Center at Dallas
  More Information Identifier: NCT00479791     History of Changes
Other Study ID Numbers: M01RR000633 ( US NIH Grant/Contract Award Number )
Study First Received: May 24, 2007
Last Updated: May 25, 2007

Keywords provided by University of Texas Southwestern Medical Center:
Type 2 diabetes mellitus
Fatty acids
Postprandial response

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Hypoglycemic Agents
Physiological Effects of Drugs processed this record on May 25, 2017