Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ALCR): Onsite Follow-up (MOON Onsite)
In this study we will examine patients who have undergone unilateral ACL reconstruction surgery to determine which structural and functional characteristics of the knee two years post reconstruction surgery, aspects of the original injury and repair, and patient characteristics are risk factors for osteoarthritis after ACL reconstruction surgery.
Rupture of Anterior Cruciate Ligament
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Multicenter Orthopaedic Outcomes Network (MOON) Anterior Cruciate Ligament (ACL) Reconstruction (ALCR): Onsite Follow-up|
- Side to side knee joint space difference as seen on x-ray [ Time Frame: 2-3.3 years post surgery ] [ Designated as safety issue: No ]
|Study Start Date:||August 2007|
|Estimated Study Completion Date:||December 2014|
|Estimated Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
The purpose of this study is identify risk factors for signs and symptoms of osteoarthritis two year post ACL reconstruction from information available at the time of surgery; including patient characteristics (age, gender, body mass index (BMI), activity level, clinical knee alignment), their injuries ("pop" heard at the time of injury, concurrent meniscus, articular cartilage, and collateral ligament injuries), and treatment decisions made during the initial surgery (e.g. meniscus and articular cartilage treatments.)
Primary outcome measures will be the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain and stiffness subscales and joint space width measured on weight-bearing radiographs.
Secondary outcome measures will include the knee related quality of life subscale of the Knee Injury and Osteoarthritis Score (KOOS) and Kellgren-Lawrence grading from weight-bearing radiographs.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00478894
|United States, Missouri|
|Washington University in St. Louis|
|St. Louis, Missouri, United States, 63110|
|United States, Ohio|
|Cleveland, Ohio, United States, 44195|
|The Ohio State University|
|Columbus, Ohio, United States, 43221|
|United States, Tennessee|
|Nashville, Tennessee, United States, 37232|
|Principal Investigator:||Kurt P Spindler, M.D.||Cleveland Clinic / Vanderbilt University|