fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease (ALZ)

This study is enrolling participants by invitation only.
Information provided by:
University of Wisconsin, Madison Identifier:
First received: May 22, 2007
Last updated: September 27, 2010
Last verified: September 2010

The purpose of this study is to investigate the organization of memory and develop future methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we examine the responsiveness of the brain to memory tasks, specifically focusing on regions of the brain (the mesial temporal lobe and posterior cingulate) that are known to be involved in early stages of Alzheimer's disease (AD). Of interest are differences in brain activation between people with and without a family history of AD and other risk factors.

Magnetic Resonance Imaging
Alzheimer's Disease
Adult Children

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease

Resource links provided by NLM:

Further study details as provided by University of Wisconsin, Madison:

Biospecimen Retention:   Samples Without DNA

plasma and serum

Estimated Enrollment: 390
Study Start Date: January 2003
Estimated Study Completion Date: July 2010
Persons with a parent with Alzheimer's disease
Persons whose parents survived to old age without memory problems
Persons with diagnosed mild cognitive impairment
Persons without memory problems


Ages Eligible for Study:   40 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Persons with a parent with Alzheimer's disease will be recruited from the Wisconsin Registry for Alzheimer's Prevention (WRAP). Persons with MCI will be recruited from the UW clinics and satellite clinics. Controls for the above study groups will be recruited from the WRAP and the local community.


Inclusion Criteria:

  • MCI Group: Diagnosis of mild cognitive impairment
  • AD Family History Group: Confirmed family history of Alzheimer's and concurrent enrollment in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
  • Control Groups: Cognitively healthy and both parents survived past age 70 with no memory problems

Exclusion Criteria:

  • Claustrophobia
  • Metallic or electronic implants or devices that are not MRI-safe
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00478491

United States, Wisconsin
University of Wisconsin - Wisconsin Comprehensive Memory Program
Madison, Wisconsin, United States, 53792
Sponsors and Collaborators
University of Wisconsin, Madison
Principal Investigator: Sterling C Johnson, PhD University of Wisconsin/VA GRECC
  More Information

Additional Information:
Responsible Party: Sterling Johnson, PhD, University of Wisconsin - Madison Identifier: NCT00478491     History of Changes
Other Study ID Numbers: 2002-515, NIH RO1 AG021155A
Study First Received: May 22, 2007
Last Updated: September 27, 2010
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Alzheimer Disease
Brain Diseases
Central Nervous System Diseases
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders
Nervous System Diseases
Neurodegenerative Diseases
Tauopathies processed this record on August 27, 2015