Posterior Cingulate Function in Persons With Risk Factors for Alzheimer's Disease (PC)

This study has been completed.
VA Office of Research and Development
Information provided by (Responsible Party):
University of Wisconsin, Madison Identifier:
First received: May 22, 2007
Last updated: October 1, 2015
Last verified: April 2011
The purpose of this study is to use fMRI techniques to explore a certain part of the brain associated with Alzheimer's disease known as the posterior cingulate. Determining the functionality of this brain region may help us diagnose AD more accurately, thus allowing earlier treatment.

Magnetic Resonance Imaging
Alzheimer's Disease
Adult Children

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Posterior Cingulate Function in Persons With Risk Factors for Alzheimer's Disease

Resource links provided by NLM:

Further study details as provided by University of Wisconsin, Madison:

Estimated Enrollment: 206
Study Start Date: July 2005
Study Completion Date: October 2007
Detailed Description:
The posterior cingulate is a key brain region suggested by recent studies to be affected in people at risk for Alzheimer's Disease (AD). Because the PC is affected very early in the course of AD and the region may have reduced function even prior to the onset of symptoms, further understanding of its functional role and its relationship to other brain regions may be helpful in detecting AD earlier and in monitoring disease progression and treatment. This project examines the role of the PC and its connections to other brain regions using functional magnetic resonance imaging (fMRI), a technique that allows us to examine the brain at work during tests of memory and decision-making. The main goal is to see if functional connections between brain regions are modulated by risk for AD.

Ages Eligible for Study:   55 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
People who are enrolled in the Wisconsin Registry for AD Prevention (WRAP), recruited from Memory clinics and the community.

Inclusion Criteria:

  • Cognitively healthy
  • (Controls Only) Parents survived past age 70 and did/do not have memory problems.

Exclusion Criteria:

  • Claustrophobia
  • Metallic or electronic implants
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00478166

United States, Wisconsin
University of Wisconsin - Wisconsin Comprehensive Memory Program
Madison, Wisconsin, United States, 53792
Sponsors and Collaborators
University of Wisconsin, Madison
VA Office of Research and Development
Principal Investigator: Sterling C Johnson, PhD University of Wisconsin/VA GRECC
  More Information

Additional Information:
No publications provided

Responsible Party: University of Wisconsin, Madison Identifier: NCT00478166     History of Changes
Other Study ID Numbers: 2004-174 
Study First Received: May 22, 2007
Last Updated: October 1, 2015
Health Authority: United States: Institutional Review Board
United States: Federal Government

Additional relevant MeSH terms:
Alzheimer Disease
Brain Diseases
Central Nervous System Diseases
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders
Nervous System Diseases
Neurodegenerative Diseases
Tauopathies processed this record on February 08, 2016