Effect of Growth Hormone on Insulin Signaling in Muscle Tissue

This study has been completed.
Aarhus University Hospital
Information provided by:
University of Aarhus
ClinicalTrials.gov Identifier:
First received: May 23, 2007
Last updated: April 20, 2009
Last verified: April 2009
The purpose of this study is to examine the effects of a physiological bolus of growth hormone on insulin signaling pathways in muscle tissue in healthy lean men.

Condition Intervention
Insulin Resistance
Device: Physiological Bolus of Growth Hormone

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
Official Title: The Effect of a Physiological Bolus of Growth Hormone (GH) on Insulin Signaling Pathways in Muscle Tissue From Healthy Adults

Resource links provided by NLM:

Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • PI3-kinase activity i muscle tissue [ Time Frame: 2 hours ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Growth Hormone Signaling Proteins in Muscle Tissue and other Insulin Signaling Proteins in Muscle Tissue [ Time Frame: 2 hours ] [ Designated as safety issue: No ]

Estimated Enrollment: 8
Study Start Date: May 2007
Study Completion Date: August 2008
Primary Completion Date: April 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: 1
Saline bolus + OGTT
Device: Physiological Bolus of Growth Hormone
0,5 mg Norditropin
GH-bolus and OGTT
Device: Physiological Bolus of Growth Hormone
0,5 mg Norditropin
Device: Physiological Bolus of Growth Hormone
0,5 mg Norditropin


Ages Eligible for Study:   18 Years to 30 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Male
  • Healthy
  • Age between 18 and 30 years
  • BMI ≤ 26

Exclusion Criteria:

  • Known present disease including diabetes mellitus
  • BMI > 26
  • Uses any medication
  • Consumes > 21 units of alcohol per week
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00477997

Department M (endocrinology and diabetes)
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
Aarhus University Hospital
Principal Investigator: Jens Otto L Jørgensen, MD, DMSc Department M (endocrinology and diabetes), Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, Denmark
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Jens Otto Lunde Jørgensen, Aarhus University Hospital
ClinicalTrials.gov Identifier: NCT00477997     History of Changes
Other Study ID Numbers: MM-GH-20070052 
Study First Received: May 23, 2007
Last Updated: April 20, 2009
Health Authority: Denmark: Ethics Committee

Keywords provided by University of Aarhus:
Growth Hormone
Insulin Signaling
GH signaling

Additional relevant MeSH terms:
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases
Hormones, Hormone Substitutes, and Hormone Antagonists
Pharmacologic Actions
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on May 02, 2016