Early Cardioprotective Effect of Sevoflurane
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|ClinicalTrials.gov Identifier: NCT00477737|
Recruitment Status : Completed
First Posted : May 24, 2007
Last Update Posted : May 24, 2007
|Condition or disease||Intervention/treatment||Phase|
|Coronary Artery Disease Off Pump Coronary Artery Bypass Surgery||Drug: Sevoflurane Drug: propofol||Phase 4|
Studies have been performed on human patients undergoing CABG surgery with cardiopulmonary bypass (CPB). Only a few studies however have evaluated the effects of volatile anesthetics during coronary artery bypass grafting on a beating heart (OPCABG) with conflicting results as far as cardiac biomarker release is concerned.
Because CPB is known to have a profound impact on cardiac function, studies performed on patients scheduled for OPCABG could evaluate more specifically the effects of the anesthetic agents themselves. Patients undergoing OPCABG have a predictable and predefined ischemic zone during surgery and represent an extremely interesting and safe model for the study of ischemia and cardiac damage in humans.
Presently, there is still no consensus on the method of administration of volatile anesthetics, including the time to begin administration, its duration, the dosage and selection of volatile anesthetics.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||32 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Early Cardioprotective Effect of Sevoflurane on Left Ventricular Performance During Coronary Artery Bypass Grafting on a Beating Heart|
|Study Start Date :||August 2006|
|Actual Study Completion Date :||December 2006|
- To evaluate cardiac function with measuring of hemodynamic parameters [ Time Frame: Measurements were performed at the following intervals: 5 minutes after anesthesia induction; at the beginning of ischemia; 15 minutes after ischemia; 15 minutes after sternum closure ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00477737
|University Hospital Dubrava|
|Zagreb, Croatia, 10000|
|Principal Investigator:||Ino Husedzinovic, MD PhD Prof||Anesthesiology and Intensive Medicine|