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Morphine Analgesia in Patients With Acute Appendicitis

This study has been completed.
Information provided by:
Tehran University of Medical Sciences Identifier:
First received: May 20, 2007
Last updated: NA
Last verified: May 2007
History: No changes posted
The purpose of the study is to evaluate morphine effect on pain reduction and diagnostic accuracy in patients admitted to emergency ward with the diagnosis of acute appendicitis.

Condition Intervention Phase
Drug: Morphine
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Supportive Care
Official Title: Double Blind Randomized Study of Morphine Analgesia in Patients With Acute Appendicitis

Resource links provided by NLM:

Further study details as provided by Tehran University of Medical Sciences:

Primary Outcome Measures:
  • Pain Intensity

Secondary Outcome Measures:
  • Diagnostic Accuracy

Enrollment: 71
Study Start Date: January 2004
Study Completion Date: March 2005
Detailed Description:

Analgesic administration for pain control in patients with acute abdominal pain, regarding acute appendicitis, is controversial. Despite the results previous studies indicating the safeness of analgesic use in ED for acute abdominal pain, physicians still prefer to postpone their use after performing surgical evaluations. Since many patients admitted to ED are unlikely to receive prompt surgical consultation, many of them need pain relief to prevent unnecessary suffering. On the other hand such pain relief must not interfere with the diagnosis and treatment of patients and do not cause any complications. Morphine is a common and effective analgesic which, if shown to have no effect on correct diagnosis of acute abdomen, can be used for this purpose.

Thus we evaluated morphine effect on pain reduction and diagnostic accuracy in patients admitted to ED with the diagnosis of acute appendicitis.


Ages Eligible for Study:   13 Years to 75 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • clinical signs of acute appendicitis
  • planned for appendectomy
  • supposed to wait for at least 1 hour in the ED before operation

Exclusion Criteria:

  • suspicion to perforated appendicitis
  • being under the age of 13
  • pregnancy (according to history and ß-HCG result)
  • opium addiction
  • systolic blood pressure of less than 90 mmHG
  • known cases of chronic obstructive pulmonary disease (COPD)
  • known sensitivity to morphine
  • history of sickle cell disease
  • self administration of analgesics before enrollment
  • refusal to participate
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Please refer to this study by its identifier: NCT00477061

Iran, Islamic Republic of
Sina General Hospital
Tehran, Iran, Islamic Republic of
Sponsors and Collaborators
Tehran University of Medical Sciences
Principal Investigator: Asieh Golozar, MD Tehran University of Medical Sciences
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00477061     History of Changes
Other Study ID Numbers: AG11
Study First Received: May 20, 2007
Last Updated: May 20, 2007

Keywords provided by Tehran University of Medical Sciences:

Additional relevant MeSH terms:
Intraabdominal Infections
Gastrointestinal Diseases
Digestive System Diseases
Cecal Diseases
Intestinal Diseases
Analgesics, Opioid
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents processed this record on April 26, 2017