Curcumin for Prevention of Oral Mucositis in Children Chemotherapy

• ClinicalTrials.gov Identifier: NCT00475683
• Recruitment Status: Completed
• First Posted: May 21, 2007
• Last Update Posted: August 18, 2015
• Sponsor: Hadassah Medical Organization
• Information provided by (Responsible Party): Shoshana Vilk, Hadassah Medical Organization

Study Description

Brief Summary:

Mucositis consists of inflammation of the mucosal membrane and is a prominent cause of patient discomfort during cancer therapy. In children receiving chemotherapy, the incidence of oral mucositis is reported to be between 40%-70%. Curcumin, a commonly-used spice in India and Southeast Asia, was shown in animal models to prevent chemotherapy and radiotherapy induced mucositis. We hypothesize that curcumin may prevent oral mucosal injury and reduce the severity of oral mucositis in children receiving chemotherapy. Thus, the aim of this study is to determine whether in children undergoing doxorubicin-containing chemotherapy, does supplementation of curcumin, when compared to placebo, decrease oral mucositis both by objective (mucositis scales) and subjective (pain scale) measurements. Effective prevention and reduction of mucosal injury may significantly improve the care we provide to children undergoing therapy for cancer.

Condition or disease	Intervention/treatment	Phase
Chemotherapy Induced Mucositis	Other: Mouth wash; Dietary Supplement: Curcumol	Phase 3

Detailed Description:

Children older than 5 years of age diagnosed with cancer and treated at the Pediatric Hematology/Oncology unit, Hadassah Medical Center will be eligible to the study. The study is designed as a cross-over study, wherein each patient serves as his or her own control, thus all included children should be scheduled to receive at least two identical curses of doxorubicin-containing chemotherapy in which the dose of doxorubicin is at least 60mg/m2 per course. The patients will be assigned to randomly receive curcumin or placebo in the 1st course, with the other regimen administered at the 2nd course. Curcumin will be given as fluid extract (1:1) at a dose of 10 drops, three times a day. Adolescents and young adults will receive the adult recommend dose, i.e. 30 drops, three times a day. Placebo will be given at the same dose. The patients will be taught to rinse the mouth with the medicine and than spit out. The therapy will be given from a day prior to the first day of the cycle for two weeks. A diary kept by the family will record each given dose. Possible side effects associated with the study drug, such as vomiting, nausea, rash, etc., will be recorded. No other adjunctive topical treatment will be used during the study. Adherence will be assessed through subject reports as well as by review of returned medications every cycle collected during the objective assessment site visits. Given the intent-to-treat analysis, all participants will be included irrespective of how much of the study medication was taken.The measurements of study outcome, i.e. OMAS score, WHO mucositis scale and visual analogue pain scale will be done on day 1,7,10,14,21 ± 1 of each chemotherapy cycle. The following data will be recorded in all cycles: duration of neutropenia, the need and length of hospitalization, use and dosage of opioid analgesia, need for total potential nutrition, blood culture positive infection and other mucositis related complications.

Study Design

• Study Type: Interventional (Clinical Trial)
• Actual Enrollment: 8 participants
• Allocation: Randomized
• Intervention Model: Crossover Assignment
• Masking: Single (Outcomes Assessor)
• Primary Purpose: Treatment
• Official Title: Randomized Cross-over Study of Curcumin for Prevention of Oral Mucositis in Children Receiving Doxorubicin Based Chemotherapy.
• Study Start Date: January 2009
• Actual Primary Completion Date: December 2010
• Actual Study Completion Date: December 2010

Arms and Interventions

Arm	Intervention/treatment
Sham Comparator: regular measurments; Mouth wash with chlorexidin	Other: Mouth wash; Mouth wash with chlorehexidin, three times a day
Experimental: Curucmol; mouth wash with curcumol and mouth wash with chlorexidin	Dietary Supplement: Curcumol; 5 ml in 50 ml water, mouthwash for 30 seconds, three times a day

Outcome Measures

Primary Outcome Measures :

1. To determine whether in children undergoing doxorubicin-containing chemotherapy, does supplementation of curcumin, when compared to placebo, decrease an objective measurement of oral mucositis? [ Time Frame: 6 weeks ]

Secondary Outcome Measures :

1. To determine whether in children undergoing doxorubicin-containing chemotherapy, does supplementation of curcumin, when compared to placebo, decrease mucositis related pain, use of opioids and parenteral nutrition. [ Time Frame: 6 weeks ]

Eligibility Criteria

• Ages Eligible for Study: 5 Years to 30 Years (Child, Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Criteria

Inclusion Criteria:

1. Children older than 5 years of age, adolescents and young adults diagnosed with cancer and treated at the Pediatric Hematology/Oncology unit, Hadassah Medical Center,
2. A crossover study design is planed wherein each patient serves as his or her own control, thus all included children should be scheduled to receive at least two identical curses of doxorubicin-containing chemotherapy in which the dose of doxorubicin is at least 60mg/m2 per course,
3. Patient's/ parent's informed consent.

Exclusion Criteria:

1. Patients treated with antiplatelet therapy or anticoagulation,
2. Patients with biliary tract obstruction,
3. Patients with preexisting oral disease, such as active oral infection, trauma to the oral mucosa or oral ulceration prior to chemotherapy,
4. Patients receiving head and neck radiation,
5. Developmentally unable to comply with curcumin mouth wash as judged by the parent or investigator.

Contacts and Locations

Locations

Israel

Hadassah Medical Organization

Jerusalem, Israel

Sponsors and Collaborators

Hadassah Medical Organization

Investigators

• Principal Investigator: Shoshana Revel-Vilk, MD; Hadassah Medical Organization

More Information

• Responsible Party: Shoshana Vilk, Prof. Shoshana Revel-Villk, Hadassah Medical Organization
• ClinicalTrials.gov Identifier: NCT00475683
• Other Study ID Numbers: Curcumin-HMO-CTIL
• First Posted: May 21, 2007
• Last Update Posted: August 18, 2015
• Last Verified: June 2011

Keywords provided by Shoshana Vilk, Hadassah Medical Organization:

Doxorubicin; Mucositis; Prevention; Curcumin

Additional relevant MeSH terms:

Mucositis; Stomatitis; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Mouth Diseases; Stomatognathic Diseases