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Older Adult Training Study With Creatine and CLA (OTR)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00473902
First Posted: May 16, 2007
Last Update Posted: May 16, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
McMaster University
  Purpose
We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (> 65 y). Our study hypothesized that administering CrM and CLA would yield greater strength and body composition benefits than the placebo group over the six months of resistance exercise

Condition Intervention
Sarcopenia Behavioral: Training Drug: Creatine Monohydrate, Conjugated Linoleic Acid

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Prevention
Official Title: Creatine Monohydrate and Conjugated Linoleic Acid Improve Strength and Body Composition Following Resistance Exercise in Older Adults

Resource links provided by NLM:


Further study details as provided by McMaster University:

Primary Outcome Measures:
  • a. Muscle and bone mass b. Knee extension strength e. Creatine content f. Muscle oxidative capacity g. Aerobic power (oxygen consumption) [ Time Frame: six months ]

Secondary Outcome Measures:
  • a. Functional capacity b. Strength with weight machines [ Time Frame: six months ]

Enrollment: 39
Study Start Date: August 2003
Study Completion Date: September 2004
Detailed Description:
Men (N=19) and women (N=20) completed six months of resistance exercise training with Creatine Monohydrate (5g/d) + Conjugated Linoleic Acid (6g/d) or placebo with randomized, double-blind, allocation.Outcomes included; strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (Ν-telopeptides).
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy,
  • Ambulatory,
  • Recreationally active,
  • Community dwelling

Exclusion Criteria:

  • Evidence of coronary heart disease;
  • Congestive heart disease;
  • Uncontrolled hypertension;
  • Chronic obstructive pulmonary disease;
  • Diabetes mellitus;
  • Renal failure;
  • Major orthopedic disability; and
  • Smoking
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00473902


Locations
Canada, Ontario
McMaster University Medical Center
Hamilton, Ontario, Canada, L8N 3Z5
Sponsors and Collaborators
Hamilton Health Sciences Corporation
Investigators
Principal Investigator: Mark A Tarnopolsky, M.D., Ph.D. McMaster University
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00473902     History of Changes
Other Study ID Numbers: Older Adult Training Study
First Submitted: May 15, 2007
First Posted: May 16, 2007
Last Update Posted: May 16, 2007
Last Verified: May 2007

Additional relevant MeSH terms:
Sarcopenia
Muscular Atrophy
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Atrophy
Pathological Conditions, Anatomical
Signs and Symptoms