Effect of Free Fatty Acids (FFA) on Androgen Precursors in Women
The purpose of this study is to determine whether free fatty acids modify the androgen levels in healthy young women.
Drug: lipid/heparin or saline/heparin infusion
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Effect of Free Fatty Acids on Androgen Precursors in Vivo in Healthy Young Women|
- change in adrenal androgens [ Time Frame: 1 day ] [ Designated as safety issue: No ]
- urinary androgen excretion [ Time Frame: 1 day ] [ Designated as safety issue: No ]
- glucocorticoid metabolism and urinary glucocorticoid excretion [ Time Frame: 1 day ] [ Designated as safety issue: No ]
|Study Start Date:||December 2006|
|Study Completion Date:||May 2008|
|Primary Completion Date:||May 2008 (Final data collection date for primary outcome measure)|
Free fatty acids (FFA) are known to play an important role by inducing insulin resistance and metabolic disturbances in obesity and type 2 diabetes. In addition, FFAs seems to have a stimulatory effect on adrenal androgen precursors in men. However, the effect of FFAs on androgen precursors and androgens in women is yet unknown.
Therefore the effect of increased FFAs on adrenal androgens and androgen precursors should be investigated in a randomized controlled cross-over trial.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00473603
|Charite, Campus Benjamin Franklin|
|Principal Investigator:||Knut Mai, MD|