Aerobic Capacity and Body Composition in Colon Cancer Patients
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Recent studies have shown that survival after a colorectal cancer diagnosis may be affected by a person's activity level and body size. This research says that for colorectal cancer patients, the less active and more obese they are, the more likely they are to have a cancer recurrence or die from their cancer. Chemotherapy has been shown to reduce activity levels, fitness, and body size in some cancer patients. However, it is not known how chemotherapy specific for colon cancer patients affects their activity levels, fitness, and body size. The main goal of our study will be to look at how chemotherapy treatments affect the fitness, activity levels, and body size in colon cancer patients. In order to do this, we will measure these variables before chemotherapy treatments, and at 1 and 6 months following the end of treatment. Our results will show how chemotherapy affects fitness, activity levels, and body size in colon cancer patients and provide data to help in designing an exercise intervention specifically for colon cancer survivors.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
histologically confirmed colon cancer (Stage III and those Stage II patients deemed high-risk
approval of the treating oncologist
scheduled to received chemotherapy
able to understand and provide written informed consent in English
18+ years of age
no uncontrolled co-morbidities (including hypertension, cardiac illness, psychiatric condition, etc.)
negative ECG as assessed during maximal graded exercise test
metastatic or recurrent colon cancer patients
any uncontrolled medical condition that would be a contraindication to exercise (assessed by treating oncologist)
unwilling to attend, travel to or participate in the assessments at all 3 time points
In addition, 10 patients meeting all of the eligibility criteria who are not scheduled to receive chemotherapy will also be recruited to the study to serve as "surgery only" controls.