The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.
The purpose of this study is to determine whether adalimumab (a TNF-alpha inhibitor) is effective in the treatment of severe and acute sciatica.
Condition or disease
Drug: adalimumab (2 subcutaneous 40 mg injections on day 0 and 7)
Sciatica and low back pain are common problems that lead to major costs in Western countries. The presence of herniated disc is generally considered as the leading cause of sciatica. However, recent findings indicate that the presence of this mechanism is not sufficient to explain all the clinical signs of radiculopathy and that inflammatory mechanisms contribute also to the pathophysiology of sciatica. Indeed, herniated discs contain large amounts of tumor necrosis factor (TNF-alpha) which can induce acute and chronic inflammation and pain. It has recently been demonstrated that TNF-alpha inhibitors (infliximab or etanercept) were able to prevent the occurrence of pain in an experimental model of sciatica. In addition, two independent preliminary studies have shown that patients treated with TNF-alpha inhibitors had better evolution than an historical control group. This study has been designed to verify the hypothesis that TNF-alpha has a major role in human sciatica and that anti-TNF-alpha agents are interesting therapeutic approaches in severe sciatica.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Male or female patients older than 18
Episode of radicular pain in one lower limb for less than 12 weeks.
Medical evaluation requiring hospitalisation because of pain or functional handicap
Patients presenting a characteristic leg pain in the L3, L4, L5, or S1 territories plus at least one of the following: :
positive straight-leg-raising test with an elevation of less than 70°
positive femoral stretched
clear clinical sign of nerve root involvement
muscle strength deficiency or
sensory disturbances in clear cut dermatome or
lower limb reflex asymmetry.
Oswestry score greater than 50
If there is a past history of radicular pain involving the same nerve root, a 6 months interval free of leg pain is required.
A confirmed herniated disc on usual imaging techniques (CT scan or MRI) in the vicinity of the clinically involved nerve root that has been performed within the last 2 years.
Written informed consent
The presence of recent (<48 hours) severe muscle weakness (<3/5) or clinical signs of cauda equina compression, requiring immediate surgery.
If surgical procedure is required but is denied, either because of surgeon's decision or because of patient's fully informed decision, then this patient could be included in the protocol.
Comorbidities such as :
Coexisting infections (Chest X-ray will be performed to all patients and tuberculin skin test in case of doubt concerning a past history of tuberculous infection).
Autoimmune disease (other than RA).
History of cancer or malign lymphoproliferative disorders (unless the patient has been declared in remission for more than 5 years)
History of demyelinating disorders.
History of intolerance to adalimumab or any of its ingredients
Previous participation in this clinical study.
Participation in another clinical study within 4 weeks prior to the start of or during this study.
Poor motivation or other emotional or intellectual problems that are likely to limit the ability of the patient to comply with the protocol requirements.
The use of cortisone prior to the inclusion IS NOT an exclusion criteria
The investigators will also be allowed to exclude an individual patient from the study and remove the blinding in case of a superimposed infection or any severe side effect during the trial.