Comparison Of Two Tablet Formulations Of SB-568859
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SB-568859 is a medication that is being developed for the treatment of atherosclerosis (hardening of the arteries). The purpose of this study is to see if there is a difference in how the human body takes up the study drug depending on how the study drug is made. This study will compare SB-568859 tablets that are made in 2 different ways. This is not a treatment study.
Comparison of the amount of SB-568859 found in the blood over a period of 6 days after a single dose of each of the two types of tablets [ Time Frame: 6 days ]
Secondary Outcome Measures
Assessment of the safety and tolerability of SB-568859 after a single dose of each of the two types of tablets based on blood and urine tests, vital signs, electrocardiograms and reporting of side effects over a period of 6 days after each dose. [ Time Frame: 6 days ]
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Ages Eligible for Study:
18 Years to 50 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Healthy men and sterile women between 18 and 50 years old
Body weight greater than 50 pounds and a body mass index between 19 and 31
No history of asthma or severe allergic reactions
No history of or current drug use
No Hepatitis or HIV/AIDS
No excessive alcohol use
No smoking or tobacco use
No use of prescription drugs, over-the-counter drugs or vitamins within 7 days
No use of herbal supplements within 14 days
No treatment with an investigational drug within 30 days.
No treatment with 4 or more investigational drugs in the last 12 months
No grapefruit or grapefruit juice in the last 7 days