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Ghrelin Levels in Early IVF Pregnancies

This study has been completed.
Information provided by:
Instituto Valenciano de Infertilidad, IVI VALENCIA Identifier:
First received: May 3, 2007
Last updated: April 27, 2017
Last verified: April 2017
In this study, we have assessed the potential prognostic value for gestational outcome of maternal ghrelin levels at very early stages of IVF pregnancies. In addition, ghrelin responses to meal intake were explored at early gestation.


Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Maternal Serum Ghrelin Levels in Early IVF Pregnancies: Lack of Prognostic Value for Gestational Outcome and Altered Post-Prandial Responses

Further study details as provided by Instituto Valenciano de Infertilidad, IVI VALENCIA:

Study Start Date: June 2004
Study Completion Date: May 2007
Detailed Description:

Ghrelin is a pleiotropic hormone recently involved in the control of growth and metabolism, whose circulating levels fluctuate in relation to food intake and body mass index. Ghrelin has been detected in the decidualized endometrium, as well as in human and rat placenta, with a distinctive temporal pattern of expression along pregnancy.

Comparison(s): A total of 106 patients undergoing IVF procedures were prospectively recruited. On d-16 and 23 after oocyte retrieval, the patients were subjected to blood sampling after overnight fasting, for determination of serum ghrelin, hCG and progesterone levels. In addition, ghrelin levels were assayed in these groups, 2-h after ingestion of a fixed-calorie meal.


Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Patients undergoing IVF
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Please refer to this study by its identifier: NCT00469807

Ivi Valencia
Valencia, Spain, 46015
Sponsors and Collaborators
Instituto Valenciano de Infertilidad, IVI VALENCIA
Study Chair: Antonio Pellicer, MD Instituto Valenciano de Infertilidad
  More Information Identifier: NCT00469807     History of Changes
Other Study ID Numbers: VLC-CV-0604-507-22
Study First Received: May 3, 2007
Last Updated: April 27, 2017

Keywords provided by Instituto Valenciano de Infertilidad, IVI VALENCIA:
Pregnancy outcome processed this record on April 28, 2017