Evaluation of NT PRO BNP Guided Therapy on Hospitalization Rate and Mortality in Patients With Chronic HF NYHA II-IY

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00469001
Recruitment Status : Completed
First Posted : May 3, 2007
Last Update Posted : September 14, 2010
Information provided by:
Hillel Yaffe Medical Center

Brief Summary:
To use continuous measurement of NT Pro BNP level as guide in therapy patients with CHF.

Condition or disease Intervention/treatment
Chronic Heart Failure Procedure: Treatment according NT Pro BNP level

Detailed Description:
Group of 100 patients with CHF, NYHA II-IY will be followed for 1 years in outpatient clinic of our hospital for hospitalization, death, 6 min walking protocol, number of decompensation as a primary end point. 50 patients will be treated according usual practice in outpatient clinics and in 50 patients will be additionally used level of NT Pro BNP as additional parameter.If level NT Pro BNP will be goes down will not be changes in treatment regiment. If level of NT Pro BNP will be increased treatment will be intensified.At the end of 1 year follow up we will compare the result of two strategies.

Study Type : Observational
Actual Enrollment : 108 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Phase 1 Study of Using BNP as Guided Parameter in Treatment HF
Study Start Date : June 2007
Actual Primary Completion Date : January 2010
Actual Study Completion Date : March 2010

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients with chronic heart failure. Half of the patients were treated by common medical practice for patients with heart failure. The other half were treated according to BNP values and common medical practice.

Inclusion Criteria:

  • Patient older 18 y.old with CHF NYHA II-IY.

Exclusion Criteria:

  • All conditions with life expectancy less than 2 years.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00469001

Hillel Yaffe Medical Center
Hadera, Israel, 38100
Sponsors and Collaborators
Hillel Yaffe Medical Center
Principal Investigator: Michael Shochat, MD, PhD Hillel Yaffe Medical Center Identifier: NCT00469001     History of Changes
Other Study ID Numbers: 00001
First Posted: May 3, 2007    Key Record Dates
Last Update Posted: September 14, 2010
Last Verified: September 2010

Keywords provided by Hillel Yaffe Medical Center:
Hospitalization and death from exacerbation CHF.

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases