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The Effct of Chitooligosaccharide on Immune Function in Healthy Adults

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ClinicalTrials.gov Identifier: NCT00468962
Recruitment Status : Completed
First Posted : May 3, 2007
Last Update Posted : May 3, 2007
Sponsor:
Information provided by:
Eulji University Hospital

Brief Summary:

Functional properties of chitooligosaccharides have been studied for antitumor activity, immunostimulating effects, antimicrobial activity, free radical scavening activity, adn angiotensin I converting enzyme inhibitory activity. Recent in vitro, and in vivo toxicity and absorbability studies have demonstrated that chitooligosaccharides have high absorbability and are essentially non-toxic. In the present study, we prepared a chitooligosaccharide with high absorbability and evaluated its effects on activation of immune function and cardiovascular funciton(lipid, atrial stiffness, etc) in healthy adults.

This study was a 8-week, randomized, double-blind clinical trial. The 30 volunteers were divided into a control group(n=10), half dose chitooligosaccaride(FACOSTM) intake group(n=10), and full dose FACOS intake group(n=10). Peripheral blood mononuclear cells(PBMCs) were isolated and cultured in 12 well plate for 48 hours. Cytokine production by PBMCs pre- and postintervention were measured simultaneously after stimulation with lipopolysaccaride.


Condition or disease Intervention/treatment Phase
Immunity Drug: FACOS (functional food) Phase 4

Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double




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Ages Eligible for Study:   20 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Criteria

Inclusion Criteria:

  • healthy adults(the ages between 20~50 year)

Exclusion Criteria:

  • food allergy and allergy skin disease
  • severe liver and kidney disease
  • pregnant, lactating women
  • cancer, stroke, etc.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00468962


Sponsors and Collaborators
Eulji University Hospital
Investigators
Principal Investigator: Hee-Jeong Choi, MD, Ph.D Eulji University Hospital

ClinicalTrials.gov Identifier: NCT00468962     History of Changes
Other Study ID Numbers: 07-05
First Posted: May 3, 2007    Key Record Dates
Last Update Posted: May 3, 2007
Last Verified: May 2007