We updated the design of this site on September 25th. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Ambient Air Pollution, Preeclampsia, and Preterm Delivery

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00468663
First Posted: May 3, 2007
Last Update Posted: April 14, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
  Purpose
An epidemiologic study of pregnant women in western Washington to measure the relationships between exposure to air pollutants and risks of preeclampsia and preterm delivery.

Condition
Preeclampsia Preterm Delivery

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Ambient Air Pollution, Preeclampsia, and Preterm Delivery

Resource links provided by NLM:


Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Enrollment: 4200
Study Start Date: July 2006
Study Completion Date: May 2009
Primary Completion Date: May 2009 (Final data collection date for primary outcome measure)
Detailed Description:
We will design models that use local traffic, weather, and population characteristics to predict monthly ambient concentrations of fine particulate matter (PM2.5) and carbon monoxide (CO). These models will be used to estimate study participants' PM2.5 and CO exposures during and before pregnancy. We will test whether these air pollutant exposures are associated with subsequent risk of preeclampsia and preterm delivery. Additionally, we will test biological markers of maternal lipid peroxidation (thiobarbituric acid reactive substances) and inflammation (high sensitivity C-reactive protein) in maternal blood samples drawn during early pregnancy. We will also examine carboxyhemoglobin measured in early-pregnancy maternal blood samples as a marker of CO exposure.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Criteria

Inclusion Criteria:

  • English speaking
  • enrolled in parent study
  • pregnant at <20 weeks gestation and attending prenatal care clinics affiliated with Swedish Medical Center and Tacoma General Hospital

Exclusion Criteria:

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00468663


Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
Investigators
Principal Investigator: Carole Rudra, Ph.D, MPH Swedish Medical Center, First Hill
Principal Investigator: Michelle A Williams, Sc.D Swedish Medical Center
  More Information

ClinicalTrials.gov Identifier: NCT00468663     History of Changes
Other Study ID Numbers: 14716-CP-001
First Submitted: May 2, 2007
First Posted: May 3, 2007
Last Update Posted: April 14, 2015
Last Verified: April 2015

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
preeclampsia
preterm delivery
lipid peroxidation
inflammation

Additional relevant MeSH terms:
Premature Birth
Pre-Eclampsia
Obstetric Labor, Premature
Obstetric Labor Complications
Pregnancy Complications
Hypertension, Pregnancy-Induced