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Ambient Air Pollution, Preeclampsia, and Preterm Delivery

This study has been completed.
Information provided by:
National Institute of Environmental Health Sciences (NIEHS) Identifier:
First received: May 2, 2007
Last updated: April 13, 2015
Last verified: April 2015
An epidemiologic study of pregnant women in western Washington to measure the relationships between exposure to air pollutants and risks of preeclampsia and preterm delivery.

Preterm Delivery

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Ambient Air Pollution, Preeclampsia, and Preterm Delivery

Resource links provided by NLM:

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Enrollment: 4200
Study Start Date: July 2006
Study Completion Date: May 2009
Primary Completion Date: May 2009 (Final data collection date for primary outcome measure)
Detailed Description:
We will design models that use local traffic, weather, and population characteristics to predict monthly ambient concentrations of fine particulate matter (PM2.5) and carbon monoxide (CO). These models will be used to estimate study participants' PM2.5 and CO exposures during and before pregnancy. We will test whether these air pollutant exposures are associated with subsequent risk of preeclampsia and preterm delivery. Additionally, we will test biological markers of maternal lipid peroxidation (thiobarbituric acid reactive substances) and inflammation (high sensitivity C-reactive protein) in maternal blood samples drawn during early pregnancy. We will also examine carboxyhemoglobin measured in early-pregnancy maternal blood samples as a marker of CO exposure.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)

Inclusion Criteria:

  • English speaking
  • enrolled in parent study
  • pregnant at <20 weeks gestation and attending prenatal care clinics affiliated with Swedish Medical Center and Tacoma General Hospital

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT00468663

Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
Principal Investigator: Carole Rudra, Ph.D, MPH Swedish Medical Center, First Hill
Principal Investigator: Michelle A Williams, Sc.D Swedish Medical Center
  More Information Identifier: NCT00468663     History of Changes
Other Study ID Numbers: 14716-CP-001
Study First Received: May 2, 2007
Last Updated: April 13, 2015

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
preterm delivery
lipid peroxidation

Additional relevant MeSH terms:
Premature Birth
Obstetric Labor, Premature
Obstetric Labor Complications
Pregnancy Complications
Hypertension, Pregnancy-Induced processed this record on April 27, 2017