The Anti-inflammatory Effects of High-fat Nutrition; Towards a Clinical Application
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|ClinicalTrials.gov Identifier: NCT00468507|
Recruitment Status : Completed
First Posted : May 2, 2007
Last Update Posted : March 31, 2010
Patients undergoing major surgery, trauma and burns are prone to develop an exacerbated inflammatory response, which is potentially lethal to the individual. Recently our group demonstrated that administration of high fat feeding prior to hemorrhagic shock attenuates severe inflammation, gut barrier loss and hepatic damage. High fat feeding releases cholecystokinin in the gut, which stimulates the autonomous nervous system and subsequently activates the efferent vagus nerve. The activated efferent fibers inhibit tissue macrophages via binding of acetylcholine to the alpha7-nicotinergic receptor.
In this study the cholecystokinin release in healthy volunteers is monitored in response to low fat and high fat food products.
|Condition or disease||Intervention/treatment||Phase|
|Trauma||Dietary Supplement: nutritional intervention with Respifor and Diasip||Early Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||18 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||The Anti-inflammatory Effects of High-fat Nutrition; Towards a Clinical Application|
|Study Start Date :||March 2007|
|Primary Completion Date :||February 2010|
|Study Completion Date :||March 2010|
Dietary Supplement: nutritional intervention with Respifor and Diasip
- CCK-release [ Time Frame: two hours ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00468507
|Maastricht, Limburg, Netherlands, 6200 MD|
|Principal Investigator:||Jan-Willem Greve, professor||Maastricht University Medical Center|