Optimizing Image Quality in Obese Patients Undergoing Coronary Computed Tomography (CT) Angiography (BMI40)
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|ClinicalTrials.gov Identifier: NCT00468195|
Recruitment Status : Completed
First Posted : May 2, 2007
Last Update Posted : March 21, 2012
|Condition or disease|
|Coronary Angiography Obesity Coronary Disease|
Obesity is one of several known risk factors to develop CAD.The CT technology has been used in a multitude of important applications around the world, and many studies have established a high accuracy in detection of specific coronary stenoses (blockages in the arteries of the heart) compared to other non-invasive modalities and invasive coronary angiography, by heart catheterization. The accuracy of coronary CT angiography (CTA) in detecting coronary disease, as compared to cardiac catheterization has been demonstrated by previous studies performed at William Beaumont Hospital. Several factors contribute to the quality of the images seen on CTA, including heart rate and respiration. Overweight and obesity are also factors that influence image quality due to a low signal to noise ratio or a "noisy image". There are no studies examining the use of various techniques to improve image quality in this high-risk population of patients.
Recent advances in multi-detector computed tomography angiography has made a noninvasive technique of diagnosis of coronary artery disease possible. Multi-detector computed tomography (MDCT) offers great promise as a risk stratification tool in patients with suspected CAD. It has been demonstrated in a multitude of accuracy studies to have a negative predictive value averaging over 95%. This leads to the hypothesis that a negative MDCT may preclude the need for invasive testing. The purpose of this study is to develop an optimal way to image obese patients without presenting an increased risk.
|Study Type :||Observational|
|Actual Enrollment :||175 participants|
|Official Title:||Optimizing Image Quality in Obese Patients Undergoing Coronary CT Angiography|
|Study Start Date :||May 2007|
|Actual Study Completion Date :||September 2010|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00468195
|United States, Michigan|
|William Beaumont Hospital|
|Royal Oak, Michigan, United States, 48073|
|Principal Investigator:||Kavitha Chinnaiyan, MD||William Beaumont Hospitals|
|Study Director:||Gilbert Raff, MD||William Beaumont Hospitals|
|Study Chair:||James Goldstein, MD||William Beaumont Hospitals|