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Holotranscobalamin Remains Unchanged During Pregnancy

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ClinicalTrials.gov Identifier: NCT00467623
Recruitment Status : Completed
First Posted : April 30, 2007
Last Update Posted : October 17, 2008
Sponsor:
Collaborator:
Information provided by:

Study Description
Brief Summary:

Background and objective: Plasma cobalamins decrease during pregnancy but it is not fully elucidated how this is reflected in the total and cobalamin saturated transport proteins, transcobalamin (total TC, holoTC) and haptocorrin (total HC, holoHC). TC transports cobalamin into the cells. The function of HC is unknown, but in contrast to TC it binds both cobalamins and cobalamin analogues.

Design and methods: Healthy pregnant women (N=141) had blood samples drawn at 18th, 32nd, 39th gestation week and 8 weeks postpartum. The protein moiety of TC and HC (total and holo) was measured by in-house ELISA methods.


Condition or disease
Vitamin B12 Deficiency

Detailed Description:

Background and objective: Plasma cobalamins decrease during pregnancy but it is not fully elucidated how this is reflected in the total and cobalamin saturated transport proteins, transcobalamin (total TC, holoTC) and haptocorrin (total HC, holoHC). TC transports cobalamin into the cells. The function of HC is unknown, but in contrast to TC it binds both cobalamins and cobalamin analogues.

Design and methods: Healthy pregnant women (N=141) had blood samples drawn at 18th, 32nd, 39th gestation week and 8 weeks postpartum. The protein moiety of TC and HC (total and holo) was measured by in-house ELISA methods.


Study Design

Study Type : Observational
Estimated Enrollment : 150 participants
Time Perspective: Prospective
Official Title: Holotranscobalamin Remains Unchanged During Pregnancy. Longitudinal Changes of Cobalamins and Its Binding Proteins During Pregnancy and Postpartum
Study Start Date : January 1995
Study Completion Date : December 1997

Resource links provided by the National Library of Medicine

MedlinePlus related topics: B Vitamins
U.S. FDA Resources

Groups and Cohorts


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Danish healthy Caucasian women >18 years of age with previous uncomplicated pregnancies and deliveries and presently with a normal pregnancy.

Exclusion Criteria:

  • >4 cigarettes smoked per day,
  • Treatment with vitamin B12, folic acid or acetyl salicylic acid,
  • Impaired renal function and clinically significant vaginal haemorrhage before first visit as well as blood haemoglobin <6.4 mmol/L at first visit.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00467623


Locations
Denmark
Nils Milman
Copenhagen, Denmark, 2100
Sponsors and Collaborators
University of Aarhus
University of Copenhagen
Investigators
Principal Investigator: Nils Milman, MD University of Copenhagen
More Information

ClinicalTrials.gov Identifier: NCT00467623     History of Changes
Other Study ID Numbers: KA-93140
First Posted: April 30, 2007    Key Record Dates
Last Update Posted: October 17, 2008
Last Verified: April 2007

Keywords provided by University of Aarhus:
Pregnancy
holotranscobalamin
cobalamin
vitamin B12 analogues
reference interval

Additional relevant MeSH terms:
Vitamin B 12 Deficiency
Vitamin B Deficiency
Avitaminosis
Deficiency Diseases
Malnutrition
Nutrition Disorders
Vitamin B 12
Vitamin B Complex
Vitamins
Micronutrients
Growth Substances
Physiological Effects of Drugs