Effect of Ezetimibe on Platelet Aggregation and LDL Tendency to Peroxidation
The aim of our study is to Estimate the reduction of LDL by ezetimibe in hypercholesterolemic patients on simvastatin.Investigate the effect of LDL lowering by ezetimibe on platelet activity and LDL tendency to peroxidation in hypercholesterolemic patients on simvastatin therapy
The hypothesis is that:
- LDL lowering by ezetimibe on-top of simvastatin in patients on fixed dose of simvastatin can reduce platelet aggregation, due to the potential decreasing of cholesterol content in the platelet membranes.
- LDL lowering by ezetimibe can lower LDL tendency to peroxidation.
|Study Design:||Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Phase 4 Study on Effect of Ezetimibe on Platelet Aggregation and LDL Tendency to Peroxidation In Hypercholesterolemic Patients on Simvastatin|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00466401
|Internal Medicine Department A ,Ziv Goverment Hospital|
|Safed, Israel, 13100|
|Principal Investigator:||Osamah Hussein, MD||Ziv Hospital|