Genetic Basis of Hemangiomas
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ClinicalTrials.gov Identifier: NCT00466375 |
Recruitment Status
:
Terminated
First Posted
: April 27, 2007
Last Update Posted
: August 29, 2017
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Condition or disease | Intervention/treatment |
---|---|
Hemangioma, Vascular Anomalies | Genetic: Cheek cell samples or blood sample (4mL) Genetic: Cheek cell sample or blood sample (4mL) |
WHAT IS INVOLVED IN THE RESEARCH STUDY?
- Buccal smear (cheek cells) or small blood sample (4 mL or 1 teaspoon) from child being seen in the Dermatology clinic having infantile hemangioma or vascular anomaly
- Buccal smear (cheek cells) or small blood sample (4 mL or 1 teaspoon) from parents of child
If you and your child agree to be in this study, the following will happen:
- Informed consent and permission to use or disclose your/your child's health information for research purposes will be obtained by Dr. Drolet, the principal investigator, or her research team. You will receive a copy of this consent form.
- A buccal swab or blood sample will be obtained from you and your child; buccal sampling involves rubbing the inside of your cheek and removing cells to perform a genetic test called "Genomewide Association (GWA).
We expect you and your child to be involved in this study until you and your child have the genetic testing performed.
Study Type : | Observational |
Actual Enrollment : | 300 participants |
Observational Model: | Family-Based |
Time Perspective: | Other |
Official Title: | Genetic Basis of Hemangiomas |
Study Start Date : | April 2007 |
Actual Primary Completion Date : | November 2014 |
Actual Study Completion Date : | May 2016 |

Group/Cohort | Intervention/treatment |
---|---|
A
Patients with a hemangioma.
|
Genetic: Cheek cell samples or blood sample (4mL)
DNA will be extracted from cheek cell or blood samples from parents and child having hemangioma.
|
B.
Patients with a vascular anomaly.
|
Genetic: Cheek cell sample or blood sample (4mL)
DNA will be extracted from cheek cell or blood samples of parents and child with a vascular anomaly.
|
- SNP [ Time Frame: 3 years ]
Biospecimen Retention: Samples With DNA

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | Child, Adult, Senior |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Study Population Inclusion Criteria:
- No limit to age
- Diagnosis of infantile hemangioma and/or vascular anomaly
- Unaffected twin sibling
- Each patient's authorized legal guardian must understand the nature of the study and must provide written informed consent. Each patient must also give assent to study participation.
Study Population Exclusion Criteria:
- Diagnosis other than infantile hemangioma or vascular anomaly
- If the lesion has resolved and cannot be confirmed as a hemangioma by clinical exam
- If the biologic parents are unwilling or unable to submit DNA samples the child will be excluded from the DNA study. Therefore, if DNA samples cannot be or are not obtained from both biologic parents, the child and family will be excluded from the study.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00466375
United States, Wisconsin | |
Children's Hospital of Wisconsin | |
Milwaukee, Wisconsin, United States, 53226 |
Principal Investigator: | Beth Drolet, MD | Medical College of Wisconsin |
Responsible Party: | Beth A Drolet, MD, Professor and Vice Chairman of Pediatric Dermatology, Medical College of Wisconsin |
ClinicalTrials.gov Identifier: | NCT00466375 History of Changes |
Other Study ID Numbers: |
Genetics of Hemangioma |
First Posted: | April 27, 2007 Key Record Dates |
Last Update Posted: | August 29, 2017 |
Last Verified: | August 2017 |
Keywords provided by Beth A Drolet, MD, Medical College of Wisconsin:
hemangioma vascular anomaly infantile hemangioma |
Additional relevant MeSH terms:
Congenital Abnormalities Hemangioma Vascular Malformations Neoplasms, Vascular Tissue |
Neoplasms by Histologic Type Neoplasms Cardiovascular Abnormalities Cardiovascular Diseases |