A Validation/Interventional Study on Stress Index in Predicting Mechanical Stress in ARDS Patients
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ClinicalTrials.gov Identifier: NCT00465374
Verified April 2007 by University of Turin, Italy. Recruitment status was: Recruiting
30% of ARDS patients ventilated according to NIH protocol presents CT scan evidence of hyperinflation. Functional analysis of pressure-time curve (Stress Index=SI) has been shown to identify this condition in experimental settings. We tested the hypothesis that the SI is an accurate predictor of mechanical stress due to overdistention in ARDS patients.
Condition or disease
Respiratory Distress Syndrome, Adult
Procedure: Change ventilatory parameters with stress index monitoring
The study presents two parts : a preliminary validation study and a clinical study.
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Ages Eligible for Study:
18 Years to 85 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Age ≥ 18 years
Diagnosis of ARDS based on American-European Consensus Conference criteria
>3 days since ARDS criteria were met and mechanical ventilation was started
History of ventricular fibrillation or tachyarrhythmia, unstable angina or myocardial infarction within preceding month