Effect of Fluvastatin on Top of Clopidogrel and Aspirin in Patients After DES Implantation on Platelet Aggregation (EFA-1)
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The purpose of the study was to determine the influence of fluvastatin and atorvastatin on platelet aggregation in patients treated with aspirin and plavix after coronary stenting. We hypothezied a positive effect of fluvastatin on platelet aggregation levels.
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Ages Eligible for Study:
18 Years to 95 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
all patients with stent implantation followed by treatment with aspirin and clopidogrel
routinely treated with acetylsalicylic 100 mg/day
acute coronary syndrome
use of a GPIIb/IIIa inhibitor
allergy to acetylsalicylic acid, clopidogrel, statins
elevated liver enzymes (> 3 x norm value)
active liver disease
recent gastrointestinal bleeding (< 3 months)
known platelet dysfunction or abnormal platelet count
indication for treatment with non-steroidal drugs
indication for long-term treatment with a drug metabolized by cytochrome p450 3A4 or 2C9