Protocol Memory Deficit in Patients With Obstructive Sleep Apnea Syndrome

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2007 by University Hospital, Grenoble.
Recruitment status was  Not yet recruiting
Information provided by:
University Hospital, Grenoble Identifier:
First received: April 20, 2007
Last updated: NA
Last verified: January 2007
History: No changes posted

The main objective of this study is to evaluate the evolution of memory deficit (verbal episodic memory, procedural memory, working memory, short-term memory) in Sleep Apnea Obstructive Syndrome (SAOS) patients after treatment by Continuous Positive Airway Pressure treatment (CPAP). For thus, we will compare memory tests in two separate groups of SAOS patients with “effective ” versus “ineffective” ( or sham) CPAP, before and 6 weeks after the beginning of the treatment. Thus we will assess the evolution of memory deficit, the effectiveness of the treatment on the evolution of memory deficit before and 6 weeks after the beginning of the treatment by “effective ” versus “ineffective” CPAP.

We feel the results of the tests of memory will show greater memory disorders in patients with SAOS before beginning the treatment rather than six weeks afterwards. Thus we hypothesise that, after the treatment by "effective" CPAP, the patients with SAOS will have greater improvement of their memory disorders than those treated by "sham CPAP".

Memory Deficit

Study Type: Observational
Study Design: Allocation: Random Sample
Time Perspective: Longitudinal
Official Title: Comparison of the Evolution of Memory Deficit in Patients With Sleep Apnea Obstructive Syndrome (SAOS) Before and After "Effective" Versus Sham Treatment by Positive Pression Continues (PPC)

Resource links provided by NLM:

Further study details as provided by University Hospital, Grenoble:

Estimated Enrollment: 40
Study Start Date: April 2007
Estimated Study Completion Date: January 2008
Detailed Description:
We want to assess the evolution, before and 6 weeks after the beginning of the treatment, of the significant differences of the performances of the various memory tests evaluating several forms of memory (episodic memory, working memory, short-term memory and procedural memory) according to the treatment for patients with SAOS (effective versus sham).

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Major patients,
  • agreeing,
  • diagnosed suffering from the SAOS,
  • regulation by the specialist in a treatment by CPAP,
  • patients do not begin the treatment
  • affiliated to the social security,
  • fluent in French.

Exclusion Criteria:

  • Patients presenting severe depressive disorders (HADS score>19),
  • intellectual deterioration (MMS< 28),
  • a functional failure of the dominant arm upper limb inhibiting realization of graphic tasks,
  • an associated oxygen treatment,
  • suffering from cancer,
  • cerebro-vascular accident,
  • pregnant or nursing women,
  • adult under supervision or trusteeship,
  • patients already included in another research protocol or in period of exclusion,
  • antidepressant and anxiolytic treatment.
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Please refer to this study by its identifier: NCT00464659

Contact: Jean-Louis JP PEPIN, ProfessorPhD 00330476765516

Laboratoire EFCR-Functional Cardio-Respiratory Exploration Laboratory
Grenoble, Isere, France
Sponsors and Collaborators
University Hospital, Grenoble
Principal Investigator: Jean-Louis JP Pépin, ProfessorPhD University Hospital, Grenoble
  More Information

Publications: Identifier: NCT00464659     History of Changes
Other Study ID Numbers: 0629
Study First Received: April 20, 2007
Last Updated: April 20, 2007
Health Authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Keywords provided by University Hospital, Grenoble:
Sleep apnea obstructive syndrome (SAOS)
memory deficit
Continuous Positive Airway Pression (CPAP)

Additional relevant MeSH terms:
Memory Disorders
Sleep Apnea, Obstructive
Nervous System Diseases
Neurobehavioral Manifestations
Neurologic Manifestations
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms
Sleep Apnea Syndromes
Sleep Disorders
Sleep Disorders, Intrinsic processed this record on November 25, 2015