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Fluorine-18-α–Methyltyrosine Positron Emission Tomography for Diagnosis and Staging of Lung Cancer

This study has been completed.
Information provided by:
Gunma University Identifier:
First received: April 20, 2007
Last updated: NA
Last verified: April 2007
History: No changes posted

Objective: L-[3-18F]-α–methyltyrosine (FMT) is an amino-acid tracer for PET. We evaluated the diagnostic usefulness of 18F-FMT PET in non-small cell lung cancer (NSCLC) patients. Tumor uptake of 18F-FMT PET was compared with 18F-FDG PET and the correlation with L-type amino acid transporter 1 (LAT1) expression also investigated.

Method: Fifty patients with NSCLC were enrolled in this study, and a pair of PET study with 18F-FMT and 18F-FDG was performed. LAT1 expression and Ki-67 labeling index of the resected tumors were analyzed by immunohistochemical study.

Carcinoma, Non-Small-Cell Lung

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Gunma University:


Ages Eligible for Study:   8 Months to 2 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • proven or suspected non-small cell lung cancer

Exclusion Criteria:

  • uncontrolled diabetes mellitus
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Please refer to this study by its identifier: NCT00464282

Sponsors and Collaborators
Gunma University
Principal Investigator: kyoichi kaira, MD Gunma Unversity Graduate School of Medicine
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00464282     History of Changes
Other Study ID Numbers: Gunma 444
Study First Received: April 20, 2007
Last Updated: April 20, 2007

Keywords provided by Gunma University:
Positron emission tomography,
Lung cancer,
Amino acid transportor 1,
Proven or suspected non-small cell lung cancer were enrolled in the study

Additional relevant MeSH terms:
Carcinoma, Non-Small-Cell Lung
Carcinoma, Bronchogenic
Bronchial Neoplasms
Lung Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action processed this record on September 25, 2017