Fluorine-18-α–Methyltyrosine Positron Emission Tomography for Diagnosis and Staging of Lung Cancer

This study has been completed.
Information provided by:
Gunma University
ClinicalTrials.gov Identifier:
First received: April 20, 2007
Last updated: NA
Last verified: April 2007
History: No changes posted

Objective: L-[3-18F]-α–methyltyrosine (FMT) is an amino-acid tracer for PET. We evaluated the diagnostic usefulness of 18F-FMT PET in non-small cell lung cancer (NSCLC) patients. Tumor uptake of 18F-FMT PET was compared with 18F-FDG PET and the correlation with L-type amino acid transporter 1 (LAT1) expression also investigated.

Method: Fifty patients with NSCLC were enrolled in this study, and a pair of PET study with 18F-FMT and 18F-FDG was performed. LAT1 expression and Ki-67 labeling index of the resected tumors were analyzed by immunohistochemical study.

Carcinoma, Non-Small-Cell Lung

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal

Resource links provided by NLM:

Further study details as provided by Gunma University:


Ages Eligible for Study:   8 Months to 2 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • proven or suspected non-small cell lung cancer

Exclusion Criteria:

  • uncontrolled diabetes mellitus
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00464282

Sponsors and Collaborators
Gunma University
Principal Investigator: kyoichi kaira, MD Gunma Unversity Graduate School of Medicine
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00464282     History of Changes
Other Study ID Numbers: Gunma 444 
Study First Received: April 20, 2007
Last Updated: April 20, 2007
Health Authority: Japan: Institutional Review Board

Keywords provided by Gunma University:
Positron emission tomography,
Lung cancer,
Amino acid transportor 1,
Proven or suspected non-small cell lung cancer were enrolled in the study

Additional relevant MeSH terms:
Carcinoma, Non-Small-Cell Lung
Bronchial Neoplasms
Carcinoma, Bronchogenic
Lung Diseases
Lung Neoplasms
Neoplasms by Site
Respiratory Tract Diseases
Respiratory Tract Neoplasms
Thoracic Neoplasms

ClinicalTrials.gov processed this record on April 27, 2016